ArticleLancet regional health. Americas2022
Adverse childhood experiences and premature mortality through mid-adulthood: A five-decade prospective study.
Article in Lancet regional health. Americas, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Impact of adverse childhood experiences on analgesia-related outcomes: a systematic review.British journal of anaesthesia · 2025Pooled it
- The impact of adverse childhood experiences on multimorbidity: a systematic review and meta-analysis.BMC medicine · 2024Pooled it
- A New Normal: An Age-Period-Cohort Analysis of the Transformed Childhood Adversity Landscape in the United States.Behavioral sciences (Basel, Switzerland) · 2026Article
- The Revised ACE Pyramid: A Contemporary Framework for Understanding Childhood Adversity and Advancing Toxic Stress Prevention and Healing.Children (Basel, Switzerland) · 2026Article
- Correlations between life course trauma on perinatal outcomes of women on community supervision - a retrospective cross sectional study.BMC pregnancy and childbirth · 2026Article
- Associations between adverse childhood experiences and progression to incident psychiatric disorders in older adults: A 22-year cohort study.Translational psychiatry · 2026Article
- Childhood adversity and trajectories of health and quality of life in Australian children and adolescents: a latent class analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- Recalled Adverse Childhood Experiences Predict Behavioral Traits Associated With an Accelerated Life History in Cebu, Philippines.American journal of human biology : the official journal of the Human Biology Council · 2026Article
- MISAPSY: childhood maltreatment, food insecurity, psychological distress and professional integration among socioeconomically disadvantaged young adults - a mixed-methods study protocol.BMC psychology · 2026Article
- Article
- Adverse Childhood Experiences and Mortality at Old Age: A Longitudinal Study from the Japan Gerontological Evaluation Study.Journal of child & adolescent trauma · 2026Article
- Reduced Adherence to Antiretroviral Therapy in Pregnant Women With HIV With Intimate Partner Violence in the United States.Open forum infectious diseases · 2026Article
- Drug-Induced Deaths and Non-Fatal Poisonings in Youth-Associations With Household Adversities and Out-Of-Home Care.Drug and alcohol review · 2026Article
- The transgenerational cycle of adverse childhood experiences: transmission and familial factors for intervention - first results of an 18-year German longitudinal study.European journal of psychotraumatology · 2025Article
- Multi-omics analysis reveal clinical-gut-brain interactions in female ibs patients with adverse childhood experiences.Biology of sex differences · 2025Article
- The impact of early childhood adversity on adult cognitive performance: The mediating roles of childhood cognitive ability and educational attainment.Social science & medicine (1982) · 2025Article
- Latent classes of adverse childhood experiences and changes in inflammation across middle age among urban-dwelling adults.Brain, behavior, and immunity · 2025Article
- Adverse Childhood Experiences, Neurocognitive Functions, and Long-Term Mortality Risk.JAMA network open · 2025Article
- Associations between adverse childhood experiences and progression to incident psychiatric disorders in older adults: A 22-year cohort study.Research square · 2025Article
- Adverse childhood experiences and preventive health care among rural US children: A cross-sectional examination of 2022 National Health Interview Survey data.The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association · 2025Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Background: Adverse childhood experiences (ACEs) can have lasting effects on adult health and survival. In this study, we aimed to examine how the cumulative number and clustering patterns of ACEs were related to premature mortality. Methods: Participants ( Findings: At the start of the follow-up for mortality in 1979, participants were 12-20 years old (Mean=15·99 years), and within the 38-year follow-up through 2016, 3 344 deaths were observed among the 46 129 CPP offspring. Five latent classes of ACEs were identified. Compared to children with Interpretation: About half of the CPP cohort experienced early life adversities that clustered into four distinct patterns, which were associated with different risk of premature mortality. It is important to deepen our understanding of how specific clusters of childhood adversities affect health and premature mortality to better inform approaches to prevention and interventions.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.