Evidence map›Paper›PMID 36467041›Full record

ArticleFrontiers in pharmacology2022

Virtual screening and drug repositioning of FDA-approved drugs from the ZINC database to identify the potential hTERT inhibitors.

Hasan Afzaal, Reem Altaf, Umair Ilyas, Shaiq Uz Zaman, Syed Damin Abbas Hamdani, Saifullah Khan, Hajra Zafar, Mustafeez Mujtaba Babar, Yongtao Duan

Abstract read
In one paragraph

Article in Frontiers in pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Pan-cancer analysis reveals the prognostic and immunomodulatory potential of super-enhancer-induced ANGPT2 and experimental validation in colorectal cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hasan AfzaalHenan Provincial Key Laboratory of Children's Genetics and Metabolic Diseases, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou University, Zhengzhou, China.
Reem AltafDepartment of Pharmacy, Iqra University, Islamabad, Pakistan.
Umair IlyasDepartment of Pharmaceutics, Faculty of Pharmaceutical Sciences, Riphah International University, Islamabad, Pakistan.
Shaiq Uz ZamanDepartment of Pharmaceutics, Faculty of Pharmaceutical Sciences, Riphah International University, Islamabad, Pakistan.
Syed Damin Abbas HamdaniDepartment of Basic Medical Sciences, Shifa College of Pharmaceutical Sciences, Shifa Tameer-e-Millat University, Islamabad, Pakistan.
Saifullah KhanInstitute of Biotechnology and Microbiology, Bacha Khan University Charsadda, Charsadda, Pakistan.
Hajra ZafarSchool of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.
Mustafeez Mujtaba BabarDepartment of Basic Medical Sciences, Shifa College of Pharmaceutical Sciences, Shifa Tameer-e-Millat University, Islamabad, Pakistan.
Yongtao DuanHenan Provincial Key Laboratory of Children's Genetics and Metabolic Diseases, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou University, Zhengzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The length of the telomeres is maintained with the help of the enzyme telomerase constituting of two components, namely, a core reverse transcriptase protein (hTERT) and RNA (hTR). It serves as a significant and universal cancer target.

Indexed as

anticancerdrug repurposinghTERT inhibitorsmolecular dynamic simulationvirtual screening

Identifiers

PMID36467041
PMCPMC9715757

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.