ReviewClinical, cosmetic and investigational dermatology2022
Post-Inflammatory Hyperpigmentation in Dark Skin: Molecular Mechanism and Skincare Implications.
Review in Clinical, cosmetic and investigational dermatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 4 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- Interventions to Prevent Postinflammatory Hyperpigmentation After Laser and Energy-Based Device Treatments: A Systematic Review and Network Meta-Analysis.Lasers in surgery and medicine · 2026Pooled it
- Axillary Hyperpigmentation Treatment: A Systematic Review of the Literature.Journal of cosmetic dermatology · 2025Pooled it
- Prevention of Post-Inflammatory Hyperpigmentation in Skin of Colour: A Systematic Review.The Australasian journal of dermatology · 2025Pooled it
- Treatment of Post-Inflammatory Hyperpigmentation in Skin of Colour: A Systematic Review.Journal of cutaneous medicine and surgeryPooled it
- Efficacy and Safety of Lebrikizumab in Adult and Adolescent Patients with Skin of Color and Moderate-to-Severe Atopic Dermatitis: Results from the Phase IIIb, Open-Label ADmirable Study.American journal of clinical dermatology · 2025Trial
- Efficacy and Tolerability of a Novel Cosmetic and Over-the-Counter Facial Acne Regimen Versus a Prescription Treatment.Journal of cosmetic dermatology · 2025Trial
- The expanding role of biocompatible hydrogels in plant-derived exosome-like nanovesicles for skin diseases: prospects and challenges.Annals of medicine · 2026Review
- Design, synthesis, biological activity and in silico evaluation of phenylthiazole derivatives as multifunctional skin-whitening agents.Molecular diversity · 2026Article
- Differentiating solar lentigines from post-inflammatory hyperpigmentation with hyperspectral imaging: A pilot study.International journal of cosmetic science · 2026Article
- Computational and Cellular Evaluation of the Anti-Melanogenic Potential of Gancidin W: Integrating Network Pharmacology and Free-Energy Analyses.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Chemical Peels in Skin of Color: A Scoping Review of Safety, Efficacy, and Practice Patterns.Cureus · 2026Review
- Atypical Persistent Pruritic Hyperpigmented Plaques in Adult-Onset Still's Disease: A Case Report From Uganda.Clinical case reports · 2026Article
- Global consensus on the management of melanin hyperpigmentation disorders.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026Review
- Racial and Skin Tone Differences in Scar Maturation: A Prospective Analysis of Aesthetic and Physiological Outcomes Using the Modified POSAS Scale.International wound journal · 2026Observational
- Management of Lymphangioma Circumscriptum via Combined Laser Therapy in Pigmented Skin: A Case Report.The American journal of case reports · 2026Article
- The Impact of Post-inflammatory Pigment Alteration After Psoriasis: Novel Data from the VISIBLE Study.Dermatology and therapy · 2026Article
- Trp-containing Peptides with Therapeutic Potential for Cutibacterium acnes Infection.Probiotics and antimicrobial proteins · 2026Article
- Self-reported side effects of tattooing: a cross-sectional study in the Swedish TABOO cohort.BMJ public health · 2026Article
- An Investigator-Blinded, Randomized Trial of a Broad-Spectrum Sunscreen Containing Sclareolide and Niacinamide for the Prevention of Post-inflammatory Hyperpigmentation in Skin of Color.Dermatology and therapy · 2026Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human skin is characterized by significant diversity in color and tone, which are determined by the quantity and distribution of melanin pigment in the epidermis. Melanin absorbs and reflects ultraviolet radiation (UVR), preventing the damage to genomic DNA in the epidermis and degradation of collagen in the dermis; therefore, darker skin types are thought to be well protected from the photodamage because of the high melanin content. However, increased content of melanin in combination with the extrinsic stress factors causing inflammation such as excess UVR, allergic reactions, or injury can also frequently lead to cosmetic problems resulting in discoloration and scarring. This review summarizes current knowledge on histopathology and likely molecular signatures of one of the most common problems, post-inflammatory hyperpigmentation (PIH). The mechanisms proposed so far are subsequently discussed in the context of other factors characterizing darker skin types. This includes the common cellular features, organization of upper skin layers, and major biomarkers, with particular emphasis on increased propensities to systemic and localized inflammation. Enhanced or prolonged inflammatory responses can not only affect the process of melanogenesis but also have been implicated in injury-related skin pathologies and aging. Finally, we summarize the major cosmetic treatments for PIH and their known anti-inflammatory targets, which can be beneficial for darker skin tones and combined with broad-spectrum filters against UVR.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.