ArticleFrontiers in immunology2022
Systemic immune-inflammation index is associated with hepatic steatosis: Evidence from NHANES 2015-2018.
Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 1 of them a synthesis that pooled it.
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Who cites it
86 citing papers in PubMed, 1 synthesis or guideline pooled it, 110 citations in OpenAlex.
- Systemic immune-inflammation index as a novel biomarker for metabolic syndrome: A systematic review and meta-analysis.Medicine · 2026Pooled it
- Targeting the immune-metabolic axis reverses orthodontics-induced systemic pathology.Signal transduction and targeted therapy · 2026Article
- Construction of a predictive model for postoperative pancreatic fistula following pancreaticoduodenectomy and an exploration of inflammatory biomarker associations.Gland surgery · 2026Article
- Selenium and Liver Steatosis and Fibrosis: Opposing Direct and Steatosis-Mediated Associations in a Large Cohort.JGH open : an open access journal of gastroenterology and hepatology · 2026Article
- Machine Learning and SHAP Value Interpretation for Predicting Hepatic Steatosis Using Vibration-Controlled Transient Elastography.International journal of endocrinology · 2026Article
- GPER1 as a therapeutic target in MASLD: evidence for steatosis attenuation by agonist G1 in preclinical models.Frontiers in pharmacology · 2026Article
- Article
- Determinants of Liver Steatosis Progression in Chinese Children: A Prospective Cohort Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Prognostic Nomogram for Hepatocellular Carcinoma Patients with High Systemic Immune-Inflammation Index: Validation in Surgical and Immunotherapy Cohorts and Exploration of Immune Microenvironment Mechanisms.Journal of hepatocellular carcinoma · 2026Article
- Atrial fibrillation identification in patients with non-alcoholic fatty liver disease: a machine learning model based on immune-inflammatory markers.Diabetology & metabolic syndrome · 2025Article
- Exploring the Systemic Immune-Inflammation Index as a novel biomarker for nonalcoholic fatty liver disease: a systematic review and meta-analysis.Annals of medicine and surgery (2012) · 2025Article
- Systemic Inflammatory Response Index Is Associated With Insufficient Weight Loss After Bariatric Surgery.World journal of surgery · 2025Observational
- Systemic Inflammation Indices, Chemokines, and Metabolic Markers in Perimenopausal Women.Nutrients · 2025Article
- Association between dietary inflammatory index and hepatic steatosis: cross-sectional evidence from the NHANES 2007-2020.Journal of health, population, and nutrition · 2025Article
- Systemic chronic inflammation mediates the effect of per- and polyfluoroalkyl substances exposure on the risk of nonalcoholic fatty liver disease: A cross-sectional study among Chinese government employees.Environmental epidemiology (Philadelphia, Pa.) · 2025Article
- A New Nomogram for Predicting Early Weight Loss Outcomes in Patients with Obesity Following Laparoscopic Sleeve Gastrectomy.Obesity surgery · 2025Article
- Relationship between weekend catch-up sleep and the risk of diabetic kidney disease.Archives of endocrinology and metabolism · 2025Article
- Association between glucose time-in-range and the severity of metabolic dysfunction-associated steatotic liver disease in Chinese adults with type 2 diabetes mellitus.BMC endocrine disorders · 2025Article
- Association between the atherogenic index of plasma and the systemic immuno-inflammatory index using NHANES data from 2005 to 2018.Scientific reports · 2025Article
- Flavonoid intake, inflammation, and atherosclerotic cardiovascular disease risk in U.S. adults: a cross-sectional study.Nutrition & metabolism · 2025Article
26 more citing papers are in PubMed but not listed here.
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6 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Background: As a novel inflammatory marker, Systemic Immune-Inflammation Index (SII) has not been studied with hepatic steatosis. The aim of this study was to investigate the possible relationship between SII and hepatic steatosis. Methods: In the cross-sectional investigation, adults having complete information on SII, hepatic steatosis, and bariatric surgery from the 2015-2018 National Health and Nutrition Examination Survey (NHANES) were included. Hepatic steatosis was evaluated with heaptic steatosis index (HSI). The platelet count × neutrophil count/lymphocyte count was used to compute SII. We investigated the independent interaction between SII and hepatic steatosis using weighted multivariable regression analysis and subgroup analysis. To explore the potential relationship between SII, bariatric surgery and hepatic steatosis by controlling potential confounders by propensity score matching. Results: The study involved 10505 participants in total, 5937 (56.5%) of whom had hepatic steatosis according to the diagnosis. After adjusted for covariates, multivariable logistic regression revealed that high SII level was an independent risk factor for hepatic steatosis (OR = 1.30, 95% CI: 1.10-1.52, P 0.01). Unexpectedly, bariatric surgery reduced SII even after PSM corrected for differences of BMI and HSI. Conclusions: In US adults, SII was positively correlated with an increase in hepatic steatosis. The SII may be a simple and affordable way to identify hepatic steatosis. Bariatric surgery may reduce SII without resorting to weight loss. This needs to be verified in additional prospective research.
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