ReviewFrontiers in molecular neuroscience2022
The modulation of emotional and social behaviors by oxytocin signaling in limbic network.
Review in Frontiers in molecular neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Exploring the efficacy of intranasal oxytocin (OXT) for anxiety and stress-related disorders through functional magnetic resonance imaging (fMRI) study: a systematic review.BMC pharmacology & toxicology · 2025Pooled it
- C-low threshold mechanoreceptors: a novel target for health-tech in an increasingly touch-deprived world.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Review
- Imaging biomarkers in functional neurological disorders.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Review
- Article
- Safety Signals Enable Single-Episode Active Avoidance paradigm and Expose Threat Generalization in Tuberous Sclerosis Complex.bioRxiv : the preprint server for biology · 2026Article
- Astrocytes mediate a positive feedback loop for oxytocin.bioRxiv : the preprint server for biology · 2026Article
- Interactive impacts of social deprivation and intranasal oxytocin administration on oxytocin receptor density in prairie vole brains.Frontiers in behavioral neuroscience · 2026Article
- What electrodes can be used to measure mu rhythm (de)synchronization in the context of speech comprehension studies? An insight from theoretical analysis.Frontiers in human neuroscience · 2026Article
- Stress-related neuroplasticity and developmental vulnerability in functional neurological disorder: from adverse experience to maladaptive overlearning.Frontiers in molecular neuroscience · 2026Review
- Neurophysiological mechanisms of embodied empathy in martial arts.Frontiers in psychology · 2026Article
- Three-dimensional quantification of oxytocin neurons in the hypothalamic paraventricular nucleus reveals sex- and subregion-specific differences in two genetic mouse models of autism.Journal of neuroendocrinology · 2025Article
- Early Life Mild Adversity Affects in a Sexually Dimorphic Way the Oxytocinergic System Reducing Close Social Interaction in Adult Male Rats.Journal of neurochemistry · 2025Article
- An overview of oxytocin integrative mechanisms in autism spectrum disorder.Discover mental health · 2025Review
- Prefrontal oxytocin receptor positive cells mediate stress-induced anxiety in tuberous sclerosis complex.Communications biology · 2025Article
- Gut Microbiota Affects Mouse Social Behavior via Hippuric Acid Metabolism.Neurology international · 2025Article
- Oxytocin, Vasopressin and Stress: A Hormetic Perspective.Current issues in molecular biology · 2025Review
- The effects of sex and age on movie-watching functional connectivity and movie clip classification.Brain structure & function · 2025Article
- The Promise of Intranasal Oxytocin in Treating Borderline Personality Disorder: A Narrative Review.Brain sciences · 2025Review
- Social dominance in rats is a determinant of susceptibility to stress.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Impaired emotion recognition in Cntnap2-deficient mice is associated with hyper-synchronous prefrontal cortex neuronal activity.Molecular psychiatry · 2025Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuropeptides can exert volume modulation in neuronal networks, which account for a well-calibrated and fine-tuned regulation that depends on the sensory and behavioral contexts. For example, oxytocin (OT) and oxytocin receptor (OTR) trigger a signaling pattern encompassing intracellular cascades, synaptic plasticity, gene expression, and network regulation, that together function to increase the signal-to-noise ratio for sensory-dependent stress/threat and social responses. Activation of OTRs in emotional circuits within the limbic forebrain is necessary to acquire stress/threat responses. When emotional memories are retrieved, OTR-expressing cells act as gatekeepers of the threat response choice/discrimination. OT signaling has also been implicated in modulating social-exposure elicited responses in the neural circuits within the limbic forebrain. In this review, we describe the cellular and molecular mechanisms that underlie the neuromodulation by OT, and how OT signaling in specific neural circuits and cell populations mediate stress/threat and social behaviors. OT and downstream signaling cascades are heavily implicated in neuropsychiatric disorders characterized by emotional and social dysregulation. Thus, a mechanistic understanding of downstream cellular effects of OT in relevant cell types and neural circuits can help design effective intervention techniques for a variety of neuropsychiatric disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.