Evidence map›Paper›PMID 36466675›Full record

ReviewFrontiers in microbiology2022

Bacteriophage-mediated manipulations of microbiota in gastrointestinal diseases.

Lynn El Haddad, Jesus F Mendoza, Christian Jobin

Abstract readReview
In one paragraph

Review in Frontiers in microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Review
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  3. Extensive library ofMicrobiology spectrum · 2026
    Article
  4. Journal of microbiology and biotechnology · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lynn El HaddadDepartment of Medicine, University of Florida, Gainesville, FL, United States.
Jesus F MendozaDepartment of Medicine, University of Florida, Gainesville, FL, United States.
Christian JobinDepartment of Medicine, University of Florida, Gainesville, FL, United States.

Funding

The role of klebsiella pneumonia-derived colibactin in colitis-associated colon cancerR01DK073338 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JOBIN, CHRISTIAN · 2007 to 2023
$5.4M
Bacteriophages as Modulators of Bacterial ColonizationK01AI166096 · NIAID · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Lynn El Haddad · 2022 to 2026
$529k
Bacteriophage-mediated microbiota modification to prevent colorectal cancer developmentR21CA264927 · NCI · UNIVERSITY OF FLORIDA · PI EL HADDAD, LYNN, JOBIN, CHRISTIAN · 2022 to 2023
$388k
NCI NIH HHS R21 CA264927NIAID NIH HHS K01 AI166096NIDDK NIH HHS R01 DK073338
6 · The paper itself

Abstract

Although some gastrointestinal diseases could be managed using various antibiotics regimen, this therapeutic approach lacks precision and damages the microbiota. Emerging literature suggests that phages may play a key role in restoring the gut microbiome balance and controlling disease progression either with exogenous phage intervention or filtered fecal transplantation or even engineered phages. In this review, we will discuss the current phage applications aiming at controlling the bacterial population and preventing infection, inflammation, and cancer progression in the context of gastrointestinal diseases.

Indexed as

bacteriomecolorectal cancergutinflammationphageomephages

Identifiers

PMID36466675
PMCPMC9714271

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.