ArticleFrontiers in microbiology2022
Tryptophan was metabolized into beneficial metabolites against coronary heart disease or prevented from producing harmful metabolites by the
Article in Frontiers in microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- The tryptophan-kynurenine pathway in cardiovascular diseases: mechanistic insights and therapeutic opportunities.Frontiers in cardiovascular medicine · 2026Review
- Gut microbiota-mitochondrial crosstalk in obesity: novel mechanistic insights and therapeutic strategies with traditional Chinese medicine.Frontiers in pharmacology · 2025Review
- Intestinal flora metabolites indole-3-butyric acid and disodium succinate promote IncI2Frontiers in cellular and infection microbiology · 2025Article
- Circulating metabolites and coronary heart disease: a bidirectional Mendelian randomization.Frontiers in cardiovascular medicine · 2024Article
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
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Abstract
In our previous study of 2,130 Chinese patients with coronary heart disease (CHD), we found that tryptophan (TRP) metabolites contributed to elevated risks of death. Many TRP-derived metabolites require the participation of intestinal bacteria to produce, and they play an important role in the pathogenesis of metabolic diseases such as CHD. So it is necessary to metabolize TRP into beneficial metabolites against CHD or prevent the production of harmful metabolites through external intervention. Indole-3-butyric acid (IBA) may be a key point of gut microbiota that causes TRP metabolism disorder and affects major adverse cardiovascular events in CHD. Therefore, this study aimed to develop a method based on
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