ArticleFrontiers in human neuroscience2022
Effect of music intervention on subjective scores, heart rate variability, and prefrontal hemodynamics in patients with chronic pain.
Article in Frontiers in human neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Effect of music intervention on heart rate variability: a systematic review and meta-analysis of randomized controlled trials.Frontiers in psychology · 2026Pooled it
- Efficacy and Safety of Transcutaneous Acupoint Electrical Stimulation in the Treatment of Cervical Spondylosis: A Multicenter Randomized Open-Labeled Controlled Clinical Study.Pain research & management · 2025Trial
- A scoping review of music-based pain treatment mechanism research.Pain reports · 2026Review
- Perioperative Anxiety in Adults: A Narrative Review of Pathophysiology, Assessment, and Multimodal Management Strategies.Healthcare (Basel, Switzerland) · 2026Review
- The therapeutic use of music for chronic pain: a psychological and neurobiological perspective.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- The psychophysiology of music-based interventions and the experience of pain.Frontiers in psychology · 2024Review
- Does Music Intervention Improve Anxiety in Dementia Patients? A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Journal of clinical medicine · 2023Review
- Potential impact of music interventions in managing diabetic conditions.World journal of clinical cases · 2023Review
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Music interventions have been proposed in recent years as a treatment for chronic pain. However, the mechanisms by which music relieves pain are unclear, and the effects of music intervention on physiological indicators in patients with chronic pain remain to be explored. This study aimed to explore whether a music intervention would have effects on subjective pain ratings, heart rate variability, and functional connectivity of the cerebral cortex in patients with chronic pain. Methods: A randomized controlled study was conducted on 37 pain patients aged 18-65 years, with the control group receiving usual care, and the intervention group receiving music intervention (8-150 Hz, 50-70 dB) for 30 min before bedtime for 7 days on top of usual care. Pain visual analog scale and heart rate variability were used as subjective and objective physiological indices before and after the music intervention, respectively. Changes in oxyhemoglobin and deoxyhemoglobin concentrations in the cerebral cortex were measured by functional near-infrared spectroscopy, and whole-brain correlation analysis was used to quantify the connectivity of prefrontal brain regions associated with the pain response. Results: Results showed that patients with chronic pain in the intervention group had significantly lower visual assessment scale scores, as well as significantly lower overall voluntary mobility during pain episodes, resulting in relatively higher vagal innervation compared to the control group. In addition, connections between the bilateral dorsolateral prefrontal cortex (BA9, BA46) and frontal areas (BA10) were significantly higher in the intervention group. Discussion: This study demonstrates the effectiveness of the combined application of music interventions with usual care in reducing pain levels in patients with chronic pain and provides insight into the pathological mechanisms of music interventions for analgesia, providing direction for new baseline indicators for quantitative clinical assessment of pain. The study was registered in the Chinese Clinical Trial Registry (No. ChiCTR2100052993). Clinical trial registration: [https://www.chictr.org.cn/showproj.aspx?proj=136268], identifier [ChiCTR2100052993].
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.