ArticleFrontiers in aging neuroscience2022
Gait variability predicts cognitive impairment in older adults with subclinical cerebral small vessel disease.
Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Cerebral small vessel disease pathology in COVID-19 patients: A systematic review.Ageing research reviews · 2023Pooled it
- Identifying cognitive impairment in older adults using machine learning on combined fNIRS and motion data during an upper extremity dual task function.Research square · 2026Article
- A Age Related Vascular Senescence: Mystery of Blood-brain Barrier Dysfunction in Neurodegeneration.Molecular neurobiology · 2026Review
- Article
- Exploring Exercise-Linked Neurovascular Unit Adaptations and Sema3G Pathway Involvement in Rats with Vascular Cognitive Impairment.Neurochemical research · 2026Article
- Linking Motor and Cognitive Decline in Aging: Gait Variability and Working Memory as Early Markers of Frailty.Healthcare (Basel, Switzerland) · 2025Article
- Age-related and dual task-induced gait alterations and asymmetry: optimizing the Semmelweis Study gait assessment protocol.GeroScience · 2025Article
- Impacts of systemic milieu on cerebrovascular and brain aging: insights from heterochronic parabiosis, blood exchange, and plasma transfer experiments.GeroScience · 2025Review
- The vasoprotective role of IGF-1 signaling in the cerebral microcirculation: prevention of cerebral microhemorrhages in aging.GeroScience · 2025Review
- Cognitive outcomes after tadalafil treatment in patients with cerebral small vessel disease: ETLAS-2 sub-study.Cerebral circulation - cognition and behavior · 2025Article
- Wearable sensors and machine learning fusion-based fall risk prediction in covert cerebral small vessel disease.Frontiers in neuroscience · 2025Article
- Hand dexterity and mobility independently predict cognition in older adults: a multi-domain regression analysis.Frontiers in aging neuroscience · 2025Article
- Article
- Inter-joint coordination with and without dopaminergic medication in Parkinson's disease: a case-control study.Journal of neuroengineering and rehabilitation · 2024Article
- Brain control of dual-task walking can be improved in aging and neurological disease.GeroScience · 2024Article
- Article
- Vascular smooth muscle cell-specific Igf1r deficiency exacerbates the development of hypertension-induced cerebral microhemorrhages and gait defects.GeroScience · 2024Article
- A wearable sensor and machine learning estimate step length in older adults and patients with neurological disorders.NPJ digital medicine · 2024Article
- Stride length and cerebellar regulation: Key features of early gait disorder in cerebral small vessel disease.CNS neuroscience & therapeutics · 2024Article
- Gait Parameters can Reflect Cognitive Performance in Older Adults with Cerebral Small Vessel Disease: A Cross-sectional Research.Current neurovascular research · 2024Article
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 2 countries.
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Abstract
Introduction: Advanced methods of gait research, including approaches to quantify variability, and orderliness/regularity/predictability, are increasingly used to identify patients at risk for the development of cognitive impairment. Cerebral small vessel disease (CSVD) is highly prevalent in older adults and is known to contribute to the development of vascular cognitive impairment and dementia (VCID). Studies in preclinical models demonstrate that subclinical alterations precede CSVD-related cognitive impairment in gait coordination. In humans, CSVD also associates with gait abnormalities. The present study was designed to test the hypothesis that increased gait variability and gait asymmetry predict a decline in cognitive performance in older adults with CSVD. Methods: To test this hypothesis, we compared cognitive performance and gait function in patients with CSVD (age: 69.8 ± 5.3 years; Results: Patients with CSVD exhibited lower performance in a visual learning test ( Discussion: Our findings provide additional evidence in support of the concept that increased gait variability and asymmetry may predict cognitive impairment in older adults with CSVD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.