SynthesisFrontiers in public health2022
Association between dry eye disease and depression: An umbrella review.
Synthesis in Frontiers in public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Dry Eye Disease and personality: a systematic review.Frontiers in medicine · 2026Pooled it
- The association between air pollution and obesity: an umbrella review of meta-analyses and systematic reviews.BMC public health · 2024Pooled it
- Association between COVID-19 and sexual health: an umbrella review.Annals of medicine · 2023Pooled it
- Objective Assessment of Visual Workload in Video Display Terminal Workers Using a Non-Invasive Monitoring System.La Medicina del lavoro · 2026Observational
- AstroOphthalmology: ocular anterior segment.NPJ microgravity · 2026Review
- Article
- When eye disease affects the mind: Psychological burden and functioning in autoimmune ophthalmology.World journal of clinical cases · 2026Article
- Correlation of ocular surface function with sleep quality, anxiety, and depression in patients with dry eye disease.World journal of psychiatry · 2026Article
- Integrated management of dry eye-depression comorbidity: mechanistic insights and temporal therapeutic strategies.Frontiers in medicine · 2026Article
- Dry Eye Disease and Psychiatric Disorders: Neuroimmune Mechanisms and Therapeutic Perspectives.International journal of molecular sciences · 2025Review
- Prevalence of dry eye disease and its association with sleep quality and depression: a hospital-based survey in Thai population.BMJ open · 2025Article
- Impact of signs and symptoms of dry eye disease on health-related quality of life: a cross-sectional population study among older adults.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Article
- Association between chronic diseases and depressive inclinations among rural middle-aged and older adults.Scientific reports · 2025Article
- Dry eye disease and psychosomatics-benefits of mind-body therapy for dry eye disease.Frontiers in medicine · 2025Review
- Tear Film Conditions and Depression Symptoms in Persons with Obesity.Diagnostics (Basel, Switzerland) · 2024Article
- Positive and negative factors of parents vaccinating their children against COVID-19: An umbrella review.Preventive medicine reports · 2024Review
- Prevalence of eye and adnexal disorders among elderly inmates in Taiwan prisons.BMC public health · 2024Article
- Dry eye disease in astronauts: a narrative review.Frontiers in physiology · 2023Review
- Application of Artificial Intelligence in Ophthalmology: An Updated Comprehensive Review.Journal of ophthalmic & vision researchReview
- The Effect of Preoperative Dry Eye Disease on the Outcome of Second (Visumax 800) Generation Keratorefractive Lenticule Extraction Surgery.In vivo (Athens, Greece)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: This umbrella review aimed to summarize the available evidence on the association between dry eye disease and depression. Methods: We searched the Pubmed, Embase, and Cochrane databases using the search string "(Dry eye syndrome OR Keratoconjunctivitis sicca OR KCS OR Aqueous tear deficiency OR Sjogren syndrome) AND (depression OR depressive symptoms) AND (meta-analysis OR systematic review)" from inception to 20 July 2022. We considered all meta-analyses investigating the association between dry eye disease and depression. Results: After summarizing the included meta-analyses, it was concluded that dry eye disease is associated with depression. The symptoms of dry eye disease affect the daily lives of patients, thus affecting their mood. However, further evidence is required to confirm this association. Conclusion: This finding highlights the importance of psychological support for patients with dry eye disease. Future clinical studies should investigate the mechanism underlying the association between dry eye disease and depression. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/, identifier: CRD42022320619.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.