ArticleFrontiers in medicine2022
Using inflammatory index to distinguish asthma, asthma-COPD overlap and COPD: A retrospective observational study.
Article in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 6 citations in OpenAlex.
- Integrative Omics of Eosinophils in Asthma and COPD: Deciphering Molecular Signatures for Targeted Therapy.Molecular diagnosis & therapy · 2026Review
- Routine Blood Biomarkers and Lung Function in Asthma-COPD Overlap versus Asthma-Only Among Hospitalized Asthma Patients: A Retrospective Cross-Sectional Study.International journal of chronic obstructive pulmonary disease · 2026Article
- The relationship of Systemic Inflammatory Index with asthma in adults: A retrospective cross-sectional study.The Journal of international medical research · 2025Article
- The diagnostic value of bronchodilator response in differentiating asthma, COPD, and ACO in fixed airflow obstruction: a retrospective study.BMC pulmonary medicine · 2025Article
- Plasma Levels of CXCL9 and MCP-3 are Increased in Asthma-COPD Overlap (ACO) Patients.International journal of chronic obstructive pulmonary disease · 2025Article
- Association Between Neutrophil to Lymphocyte Ratio/Serum Albumin Ratio and Chronic Obstructive Pulmonary Disease: Results from NHANES 1999-2018.International journal of chronic obstructive pulmonary disease · 2025Article
- Clinical markers predict the efficacy of several immune checkpoint inhibitors in patients with non-small cell lung cancer in China.Frontiers in immunology · 2023Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Although asthma and chronic obstructive pulmonary disease (COPD) are two well-defined and distinct diseases, some patients present combined clinical features of both asthma and COPD, particularly in smokers and the elderly, a condition termed as asthma-COPD overlap (ACO). However, the definition of ACO is yet to be established and clinical guidelines to identify and manage ACO remain controversial. Therefore, in this study, inflammatory biomarkers were established to distinguish asthma, ACO, and COPD, and their relationship with the severity of patients' symptoms and pulmonary function were explored. Materials and methods: A total of 178 patients, diagnosed with asthma ( Result: The results showed that, compared with ACO, the higher the indexes of platelet, neutrophil-lymphocyte ratio (NLR) and eosinophil-basophil ratio (EBR), the more likely the possibility of asthma and COPD in patients, while the higher the eosinophils, the less likely the possibility of asthma and COPD. Hemoglobin and lymphocyte-monocyte ratio (LMR) were negatively correlated with the severity of patients' symptoms, while platelet-lymphocyte ratio (PLR) was negatively correlated with forced expiratory volume in the 1 s/forced vital capacity (FEV Conclusion: Inflammatory indexes are biomarkers for distinguishing asthma, ACO, and COPD, which are of clinical significance in therapeutic strategies and prognosis evaluation.
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