Evidence map›Paper›PMID 36465905›Full record

ArticleFrontiers in medicine2022

AlphaBet: Combination of Radium-223 and [

Louise Kostos, James P Buteau, Theresa Yeung, Juliana Di Iulio, Jing Xie, Anthony Cardin, Kwang Y Chin, Brittany Emmerson, Katie L Owen, Belinda S Parker and 4 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05383079 (Combination of Radium-223 and Lutetium-177 PSMA-I&T in Men with Metastatic Castration-Resistant Prostate Cancer), which is not on this map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05383079 phase1 / phase2active not recruitingnot on this map

Combination of Radium-223 and Lutetium-177 PSMA-I&T in Men with Metastatic Castration-Resistant Prostate Cancer

TypeinterventionalSponsorPeter MacCallum Cancer Centre, AustraliaRan2022 to 2026Enrolled36ConditionsMetastatic Castration-resistant Prostate Cancer, MCRPC, Prostate CancerArmsLutetium-177 PSMA-I&T, Radium-223
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 42 citations in OpenAlex.

  1. Preliminary evaluation of a novel PSMA-targeting radiopharmaceutical [European journal of nuclear medicine and molecular imaging · 2025
    Trial
  2. Pivotal Phase 3 Theranostic Trials: Future Indications.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Review
  3. Article
  4. Combination therapy strategies in engineeredCell communication and signaling : CCS · 2026
    Review
  5. PretargetedTheranostics · 2026
    Article
  6. Article
  7. Combination prostate-specific membrane antigen-targeted radiopharmaceutical therapy in metastatic prostate cancer.The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of... · 2025
    Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. DNA Damage and Repair in PBMCs after Internal Ex Vivo Irradiation with [International journal of molecular sciences · 2024
    Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Sequential and Combination Therapies ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  20. Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Louise KostosDepartment of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
James P ButeauSir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia.
Theresa YeungCentre for Biostatistics and Clinical Trials (BaCT), Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Juliana Di IulioCentre for Biostatistics and Clinical Trials (BaCT), Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Jing XieCentre for Biostatistics and Clinical Trials (BaCT), Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Anthony CardinSir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia.
Kwang Y ChinSir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia.
Brittany EmmersonMolecular Imaging and Therapeutic Nuclear Medicine, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Katie L OwenSir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia.
Belinda S ParkerSir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia.
Heidi FettkeSir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia.
Luc FuricSir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia.
Arun A AzadDepartment of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Michael S HofmanSir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia.
Peter MacCallum Cancer Centre · AUUniversity of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: [ Methods: This is a single-center, single-arm phase I/II trial evaluating the combination of Conclusion: The AlphaBet trial is a phase I/II study combining Study registration: NCT05383079.

Indexed as

177Lu-PSMAalpha therapymetastatic castration-resistant prostate cancermicrometastatic diseasePSMAradium-223

Identifiers

PMID36465905
PMCPMC9716623
OpenAlexW4309457796

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.