Evidence map›Paper›PMID 36465898›Full record

ArticleFrontiers in medicine2022

PET image enhancement using artificial intelligence for better characterization of epilepsy lesions.

Anthime Flaus, Tahya Deddah, Anthonin Reilhac, Nicolas De Leiris, Marc Janier, Ines Merida, Thomas Grenier, Colm J McGinnity, Alexander Hammers, Carole Lartizien and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. EANM practice guidelines for an appropriate use of PET and SPECT for patients with epilepsy.European journal of nuclear medicine and molecular imaging · 2024
    Guideline
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Characterisation of a novel [EJNMMI research · 2023
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 3 countries.

Anthime FlausDepartment of Nuclear Medicine, Hospices Civils de Lyon, Lyon, France.
Tahya DeddahCERMEP-Life Imaging, Lyon, France.
Anthonin ReilhacBrain Health Imaging Centre, Center for Addiction and Mental Health (CAHMS), Toronto, ON, Canada.
Nicolas De LeirisDepartement of Nuclear Medicine, CHU Grenoble Alpes, University Grenoble Alpes, Grenoble, France.
Marc JanierDepartment of Nuclear Medicine, Hospices Civils de Lyon, Lyon, France.
Ines MeridaCERMEP-Life Imaging, Lyon, France.
Thomas GrenierUniv Lyon, INSA-Lyon, Université Claude Bernard Lyon 1, CNRS, INSERM, CREATIS UMR 5220, Lyon, France.
Colm J McGinnityUniv Lyon, INSA-Lyon, Université Claude Bernard Lyon 1, CNRS, INSERM, CREATIS UMR 5220, Lyon, France.
Alexander HammersKing's College London and Guy's and St Thomas' PET Centre, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.
Carole LartizienUniv Lyon, INSA-Lyon, Université Claude Bernard Lyon 1, CNRS, INSERM, CREATIS UMR 5220, Lyon, France.
Nicolas CostesLyon Neuroscience Research Center, INSERM U1028/CNRS UMR5292, Lyon, France.
Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé · FRCentre d'Exploration et de Recherche Médicale par Emission de Positons · FRCentre for Addiction and Mental Health · CAInserm · FRKing's College London · GBUniversité Claude Bernard Lyon 1 · FRUniversité Grenoble Alpes · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: [ Methods: We created 210 numerical brain phantoms (MRI segmented into 9 regions) and assigned 10 different plausible activity values (e.g., GM/WM ratios) resulting in 2100 ground truth high quality (GT-HQ) PET phantoms. With a validated Monte-Carlo PET simulator, we then created 2100 simulated standard quality (S-SQ) [ Results: Compared to S-SQ PET, P-HQ PET improved PNSR, SSIM and RMSE; significatively improved GM RCs (from 0.29 ± 0.03 to 0.79 ± 0.04) and WM RCs (from 0.49 ± 0.03 to 1 ± 0.05); mean COVs were not statistically different. Visual lesion detection improved from 38 to 75%, with average RLA decreasing from 0.83 ± 0.08 to 0.67 ± 0.14. Visual quality of P-HQ clinical PET improved as well as reader confidence. Conclusion: P-HQ PET showed improved image quality compared to S-SQ PET across several objective quantitative metrics and increased detectability of simulated lesions. In addition, the model generalized to clinical data. Further evaluation is required to study generalization of our method and to assess clinical performance in larger cohorts.

Indexed as

brainclinical applicationdeblurringdeep learningfocal cortical dysplasia (FCD)Monte-Carlo simulationresidual networksuper resolution (SR)

Identifiers

PMID36465898
PMCPMC9708713
OpenAlexW4309308368

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.