Evidence map›Paper›PMID 36465608›Full record

ArticleFrontiers in endocrinology2022

A role for steroid 5 alpha-reductase 1 in vascular remodeling during endometrial decidualization.

Isaac W Shaw, Phoebe M Kirkwood, Diane Rebourcet, Fiona L Cousins, Rebecca J Ainslie, Dawn E W Livingstone, Lee B Smith, Philippa T K Saunders, Douglas A Gibson

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Endometriosis and Adenomyosis: From Pathogenesis to Follow-Up.Current issues in molecular biology · 2025
    Review
  6. Article
  7. [Molecular mechanism of high-altitude hypoxia-induced lipid metabolism disorder in mouse spleen tissue].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024
    Article
  8. Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Isaac W ShawCentre for Inflammation Research, The University of Edinburgh, Edinburgh, United Kingdom.
Phoebe M KirkwoodCentre for Inflammation Research, The University of Edinburgh, Edinburgh, United Kingdom.
Diane RebourcetMRC Centre for Reproductive Health, The University of Edinburgh, Edinburgh, United Kingdom.
Fiona L CousinsCentre for Inflammation Research, The University of Edinburgh, Edinburgh, United Kingdom.
Rebecca J AinslieCentre for Inflammation Research, The University of Edinburgh, Edinburgh, United Kingdom.
Dawn E W LivingstoneCentre for Discovery Brain Science, The University of Edinburgh, Edinburgh, United Kingdom.
Lee B SmithMRC Centre for Reproductive Health, The University of Edinburgh, Edinburgh, United Kingdom.
Philippa T K SaundersCentre for Inflammation Research, The University of Edinburgh, Edinburgh, United Kingdom.
Douglas A GibsonCentre for Inflammation Research, The University of Edinburgh, Edinburgh, United Kingdom.
University of Edinburgh · GBCentre for Inflammation Research · GB

Funding

Medical Research Council G1100356/1Medical Research Council MR/N002970/1Medical Research Council MR/N024524/1Wellcome Trust 072217/Z/03/ZWellcome Trust 220656/Z/20/Z
6 · The paper itself

Abstract

Decidualization is the hormone-dependent process of endometrial remodeling that is essential for fertility and reproductive health. It is characterized by dynamic changes in the endometrial stromal compartment including differentiation of fibroblasts, immune cell trafficking and vascular remodeling. Deficits in decidualization are implicated in disorders of pregnancy such as implantation failure, intra-uterine growth restriction, and pre-eclampsia. Androgens are key regulators of decidualization that promote optimal differentiation of stromal fibroblasts and activation of downstream signaling pathways required for endometrial remodeling. We have shown that androgen biosynthesis,

Indexed as

3-Oxo-5-alpha-Steroid 4-DehydrogenaseDeciduaVascular RemodelingAndrogensAnimalsCholestenone 5 alpha-ReductaseDihydrotestosteroneEndometriumFemaleMembrane ProteinsMicePregnancyVascular Endothelial Growth Factor A3-Oxo-5-alpha-Steroid 4-DehydrogenaseAndrogensCholestenone 5 alpha-ReductaseDihydrotestosteroneMembrane ProteinsSrd5a1 protein, mouseVascular Endothelial Growth Factor Avascular endothelial growth factor A, mouse5 alpha-reductaseandrogenangiogenesisdecidualizationdihydrotestosteronefinasterideintracrinologyvascular remodeling

Identifiers

PMID36465608
PMCPMC9709457
OpenAlexW4309315785

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.