Evidence map›Paper›PMID 36465552›Full record

ArticleJACS Au2022

[5]-Helistatins: Tubulin-Binding Helicenes with Antimitotic Activity.

James L Rushworth, Aditya R Thawani, Elena Fajardo-Ruiz, Joyce C M Meiring, Constanze Heise, Andrew J P White, Anna Akhmanova, Jochen R Brandt, Oliver Thorn-Seshold, Matthew J Fuchter

Abstract read
In one paragraph

Article in JACS Au, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

James L RushworthDepartment of Chemistry, Molecular Sciences Research Hub, Imperial College London, White City Campus, 82 Wood Lane, London W12 OBZ, U.K.
Aditya R ThawaniDepartment of Chemistry, Molecular Sciences Research Hub, Imperial College London, White City Campus, 82 Wood Lane, London W12 OBZ, U.K.ORCID https://orcid.org/0000-0003-0388-9055
Elena Fajardo-RuizDepartment of Pharmacy, Ludwig-Maximilians University of Munich, Munich 81377, Germany.
Joyce C M MeiringCell Biology, Neurobiology and Biophysics, Department of Biology, Faculty of Science, Utrecht University, Utrecht 3584 CH, Netherlands.
Constanze HeiseDepartment of Pharmacy, Ludwig-Maximilians University of Munich, Munich 81377, Germany.
Andrew J P WhiteDepartment of Chemistry, Molecular Sciences Research Hub, Imperial College London, White City Campus, 82 Wood Lane, London W12 OBZ, U.K.
Anna AkhmanovaCell Biology, Neurobiology and Biophysics, Department of Biology, Faculty of Science, Utrecht University, Utrecht 3584 CH, Netherlands.
Jochen R BrandtDepartment of Chemistry, Molecular Sciences Research Hub, Imperial College London, White City Campus, 82 Wood Lane, London W12 OBZ, U.K.ORCID https://orcid.org/0000-0001-7082-6201
Oliver Thorn-SesholdDepartment of Pharmacy, Ludwig-Maximilians University of Munich, Munich 81377, Germany.ORCID https://orcid.org/0000-0003-3981-651X
Matthew J FuchterDepartment of Chemistry, Molecular Sciences Research Hub, Imperial College London, White City Campus, 82 Wood Lane, London W12 OBZ, U.K.ORCID https://orcid.org/0000-0002-1767-7072

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Helicenes are high interest synthetic targets with unique conjugated helical structures that have found important technological applications. Despite this interest, helicenes have had limited impact in chemical biology. Herein, we disclose a first-in-class antimitotic helicene,

Identifiers

PMID36465552
PMCPMC9709948

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.