Evidence map›Paper›PMID 36465279›Full record

ArticleCell genomics2022

Single-cell genome-wide association reveals that a nonsynonymous variant in

Benjamin H Schott, Liuyang Wang, Xinyu Zhu, Alfred T Harding, Emily R Ko, Jeffrey S Bourgeois, Erica J Washington, Thomas W Burke, Jack Anderson, Emma Bergstrom and 9 more

Open access · goldAbstract read
In one paragraph

Article in Cell genomics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 2 countries.

Benjamin H SchottDepartment of Molecular Genetics and Microbiology, School of Medicine, Duke University, 0048B CARL Building Box 3053, 213 Research Drive, Durham, NC 27710, USA.
Liuyang WangDepartment of Molecular Genetics and Microbiology, School of Medicine, Duke University, 0048B CARL Building Box 3053, 213 Research Drive, Durham, NC 27710, USA.
Xinyu ZhuDepartment of Molecular Genetics and Microbiology, School of Medicine, Duke University, 0048B CARL Building Box 3053, 213 Research Drive, Durham, NC 27710, USA.
Alfred T HardingDepartment of Molecular Genetics and Microbiology, School of Medicine, Duke University, 0048B CARL Building Box 3053, 213 Research Drive, Durham, NC 27710, USA.
Emily R KoCenter for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC 27710, USA.
Jeffrey S BourgeoisDepartment of Molecular Genetics and Microbiology, School of Medicine, Duke University, 0048B CARL Building Box 3053, 213 Research Drive, Durham, NC 27710, USA.
Erica J WashingtonDepartment of Biochemistry, School of Medicine, Duke University, Durham, NC 27710, USA.
Thomas W BurkeCenter for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC 27710, USA.
Jack AndersonCenter for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC 27710, USA.
Emma BergstromSection of Infectious Diseases and Immunity, Imperial College London, London, W12 0NN, UK.
Zoe GardenerSection of Infectious Diseases and Immunity, Imperial College London, London, W12 0NN, UK.
Suzanna PatersonSection of Infectious Diseases and Immunity, Imperial College London, London, W12 0NN, UK.
Richard G BrennanDepartment of Biochemistry, School of Medicine, Duke University, Durham, NC 27710, USA.
Christopher ChiuSection of Infectious Diseases and Immunity, Imperial College London, London, W12 0NN, UK.
Micah T McClainCenter for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC 27710, USA.
Christopher W WoodsCenter for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC 27710, USA.
Simon G GregoryDuke Molecular Physiology Institute, Duke University Medical Center, Durham, NC 27710, USA.
Nicholas S HeatonDepartment of Molecular Genetics and Microbiology, School of Medicine, Duke University, 0048B CARL Building Box 3053, 213 Research Drive, Durham, NC 27710, USA.
Dennis C KoDepartment of Molecular Genetics and Microbiology, School of Medicine, Duke University, 0048B CARL Building Box 3053, 213 Research Drive, Durham, NC 27710, USA.
Duke University · USImperial College London · GBDuke Medical Center · US

Funding

Genetic Contributors to the Impact of Sex on Heterogeneity in Flu InfectionR01AI170089 · NIAID · DUKE UNIVERSITY · PI Dennis Chun-Yone Ko · 2022 to 2026
$2.6M
Human Genetic Variation Regulating Transcriptional Response and Cellular Susceptibility to InfluenzaR21AI153812 · NIAID · DUKE UNIVERSITY · PI KO, DENNIS CHUN-YONE · 2021 to 2022
$431k
Mechanisms of methylthioadenosine signaling during Salmonella infectionF31AI143147 · NIAID · DUKE UNIVERSITY · PI BOURGEOIS, JEFFREY · 2019 to 2021
$105k
NIAID NIH HHS F31 AI143147NIAID NIH HHS R01 AI170089NIAID NIH HHS R21 AI153812
6 · The paper itself

Abstract

During pandemics, individuals exhibit differences in risk and clinical outcomes. Here, we developed single-cell high-throughput human

Identifiers

PMID36465279
PMCPMC9718543
OpenAlexW4308739959

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.