Evidence map›Paper›PMID 36465125›Full record

ArticleiScience2022

Inhibition of the LRRC8A channel promotes microglia/macrophage phagocytosis and improves outcomes after intracerebral hemorrhagic stroke.

Jing Liu, Danmin Shen, Chao Wei, Weihua Wu, Zhaoli Luo, Liye Hu, Zhongnan Xiao, Tingting Hu, Qingyu Sun, Xiaotong Wang and 12 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 4 institutions in 2 countries.

Jing LiuDepartment of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Danmin ShenDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Chao WeiDepartment of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Weihua WuDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Zhaoli LuoDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Liye HuDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Zhongnan XiaoDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Tingting HuDepartment of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Qingyu SunDepartment of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Xiaotong WangDepartment of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Yumeng DingDepartment of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Meng LiuDepartment of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Miaoyi PangSchool of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Kaiyuan GaiSchool of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Yiran MaSchool of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Yichen TianSchool of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Yan YuChinese Institute of Rehabilitation Science, China Rehabilitation Research Center, Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing 100068, China.
Peipei WangDepartment of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Yun GuanDepartment of Anesthesiology and Critical Care Medicine, the Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA.
Meng XuDepartment of Musculoskeletal Tumor, Senior Department of Orthopedics, the Fourth Medical Center of PLA General Hospital, Beijing 100142, China.
Fei YangDepartment of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Qian LiDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Capital Medical University · CNChina Rehabilitation Research Center · CNChinese PLA General Hospital · CNJohns Hopkins University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Promoting microglial/macrophage (M/Mφ) phagocytosis accelerates hematoma clearance and improves the prognosis of intracerebral hemorrhagic stroke (ICH). Cation channels such as Piezo1 modulate bacterial clearance by regulating M/Mφ. Whether LRRC8A, an anion channel, affects M/Mφ erythrophagocytosis and functional recovery after ICH was investigated here. We found that LRRC8A is highly expressed on M/Mφ in the perihematomal region of ICH mice. Conditional knockout of

Indexed as

Immunology and neurology

Identifiers

PMID36465125
PMCPMC9708789
OpenAlexW4309047221

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.