Evidence map›Paper›PMID 36465103›Full record

ArticleiScience2022

PERIOD 2 regulates low-dose radioprotection via PER2/pGSK3β/β-catenin/Per2 loop.

Aris T Alexandrou, Yixin Duan, Shanxiu Xu, Clifford Tepper, Ming Fan, Jason Tang, Jonathan Berg, Wassim Basheer, Tyler Valicenti, Paul F Wilson and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Clock gene Per2 modulates epidermal tissue repair in vivo.Journal of cellular biochemistry · 2024
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 1 country.

Aris T AlexandrouDepartment of Radiation Oncology, University of California at Davis, 4501 X Street, Sacramento, CA 95817, USA.
Yixin DuanDepartment of Radiation Oncology, University of California at Davis, 4501 X Street, Sacramento, CA 95817, USA.
Shanxiu XuDepartment of Surgery, School of Medicine, University of California at Davis, Sacramento, CA 95817, USA.
Clifford TepperDepartment of Biochemistry and Molecular Medicine, University of California at Davis, Sacramento, CA 95817, USA.
Ming FanDepartment of Radiation Oncology, University of California at Davis, 4501 X Street, Sacramento, CA 95817, USA.
Jason TangDepartment of Radiation Oncology, University of California at Davis, 4501 X Street, Sacramento, CA 95817, USA.
Jonathan BergDepartment of Radiation Oncology, University of California at Davis, 4501 X Street, Sacramento, CA 95817, USA.
Wassim BasheerDepartment of Radiation Oncology, University of California at Davis, 4501 X Street, Sacramento, CA 95817, USA.
Tyler ValicentiDepartment of Radiation Oncology, University of California at Davis, 4501 X Street, Sacramento, CA 95817, USA.
Paul F WilsonDepartment of Radiation Oncology, University of California at Davis, 4501 X Street, Sacramento, CA 95817, USA.
Matthew A ColemanDepartment of Radiation Oncology, University of California at Davis, 4501 X Street, Sacramento, CA 95817, USA.
Andrew T VaughanDepartment of Radiation Oncology, University of California at Davis, 4501 X Street, Sacramento, CA 95817, USA.
Loning FuDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
David J GrdinaDepartment of Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637, USA.
Jefferey MurleyDepartment of Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637, USA.
Aijun WangDepartment of Surgery, School of Medicine, University of California at Davis, Sacramento, CA 95817, USA.
Gayle WoloschakDepartment of Radiation Oncology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60637, USA.
Jian Jian LiDepartment of Radiation Oncology, University of California at Davis, 4501 X Street, Sacramento, CA 95817, USA.
University of California, Davis · USUniversity of Chicago · USBaylor College of Medicine · USHoly Cross College · USNorthwestern University · US

Funding

Staff InvestigatorsP30CA093373 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI KC KENT LLOYD · 2002 to 2026
$84.9M
(PQ6)Nuclear receptor mechanisms in circadian disruption induced hepatocarcinogenesisR01CA230848 · NCI · BAYLOR COLLEGE OF MEDICINE · PI FU, LONING NONE, MOORE, DAVID D · 2018 to 2022
$2.3M
Sympathetic circadian dysfunction in obesity-related hepatocarcinogenesisR01CA238988 · NCI · BAYLOR COLLEGE OF MEDICINE · PI FU, LONING NONE, MOORE, DAVID D · 2019 to 2023
$2.2M
Mitochondrial bioenergetics is associated with aggressive breast cancer growthR01CA213830 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LI, JIAN JIAN · 2017 to 2021
$1.8M
NCI NIH HHS P30 CA093373NCI NIH HHS R01 CA213830NCI NIH HHS R01 CA230848NCI NIH HHS R01 CA238988
6 · The paper itself

Abstract

During evolution, humans are acclimatized to the stresses of natural radiation and circadian rhythmicity. Radiosensitivity of mammalian cells varies in the circadian period and adaptive radioprotection can be induced by pre-exposure to low-level radiation (LDR). It is unclear, however, if clock proteins participate in signaling LDR radioprotection. Herein, we demonstrate that radiosensitivity is increased in mice with the deficient Period 2 gene (Per2

Indexed as

Biological sciencescell biologymolecular biology

Identifiers

PMID36465103
PMCPMC9708791
OpenAlexW4308620347

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.