ArticleMicrobiome2022
Taurine metabolism is modulated in Vibrio-infected Penaeus vannamei to shape shrimp antibacterial response and survival.
Article in Microbiome, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 31 citations in OpenAlex.
- Integrated Transcriptomic and Metabolomic Analysis Reveals the Regulatory Mechanisms ofBiology · 2026Article
- Hexosamine biosynthesis drives hemocyanin O-GlcNAcylation to potentiate antibacterial immunity in shrimp.The Journal of biological chemistry · 2026Article
- Precisely designed keystone metabolites boost shrimp disease resistance by recruiting symbionts via the lipoxin A4-AP-1 pathway.Microbiome · 2026Article
- Dephosphorylation at Ser548 regulates hemocyanin-derived antibacterial peptides and immune defense iniScience · 2026Article
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- In-depth characterization of virulence traits, pathogenicity, antibiogram, and antibiotic resistance genes of MDR Vibrio parahaemolyticus retrieved from shrimp.Scientific reports · 2025Article
- Linear Ubiquitination of Hemocyanin Mediated by LUBEL Regulates Innate Immunity inInternational journal of molecular sciences · 2025Article
- Integrated m6A RNA methylation and transcriptomic analysis of Apostichopus japonicus under combined high-temperature and hypoxia stress.BMC genomics · 2025Article
- Effects of Lysophospholipids on the Antioxidant Capacity, Digestive Performance, and Intestinal Microbiota ofBiology · 2025Article
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- Las Bolitas Syndrome inMicroorganisms · 2024Article
- Rationally designed probiotics prevent shrimp white feces syndrome via the probiotics-gut microbiome-immunity axis.NPJ biofilms and microbiomes · 2024Article
- Effects of Dietary Taurine on Maturation Indices, Antioxidant Capacity, Ovaries Amino and Fatty Acids Profile, and Vitellogenin Gene Transcription Level inAquaculture nutrition · 2024Article
- The Combination of Antibiotic and Non-Antibiotic Compounds Improves Antibiotic Efficacy against Multidrug-Resistant Bacteria.International journal of molecular sciences · 2023Review
- Article
- Kruppel homolog 1 modulates ROS production and antimicrobial peptides expression in shrimp hemocytes during infection by theFrontiers in immunology · 2023Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNumerous microorganisms are found in aquaculture ponds, including several pathogenic bacteria. Infection of cultured animals by these pathogens results in diseases and metabolic dysregulation. However, changes in the metabolic profiles that occur at different infection stages in the same ponds and how these metabolic changes can be modulated by exogenous metabolites in Penaeus vannamei remain unknown.
resultsHere, we collected gastrointestinal tract (GIT) samples from healthy, diseased, and moribund P. vannamei in the same aquaculture pond for histological, metabolic, and transcriptome profiling. We found that diseased and moribund shrimp with empty GITs and atrophied hepatopancreas were mainly infected with Vibrio parahaemolyticus and Vibrio harveyi. Although significant dysregulation of crucial metabolites and their enzymes were observed in diseased and moribund shrimps, diseased shrimp expressed high levels of taurine and taurine metabolism-related enzymes, while moribund shrimp expressed high levels of hypoxanthine and related metabolism enzymes. Moreover, a strong negative correlation was observed between taurine levels and the relative abundance of V. parahaemolyticus and V. harveyi. Besides, exogenous taurine enhanced shrimp survival against V. parahaemolyticus challenge by increasing the expression of key taurine metabolism enzymes, mainly, cysteine dioxygenase (CDO) and cysteine sulfinic acid decarboxylase (CSD).
conclusionsOur study revealed that taurine metabolism could be modulated by exogenous supplementation to improve crustacean immune response against pathogenic microbes. Video Abstract.
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