Evidence map›Paper›PMID 36463945›Full record

ArticleEuropean journal of pharmacology2023

Malate reduced blood pressure and exerted differential effects on renal hemodynamics; role of the nitric oxide system and renal epithelial sodium channels (E

Osaze Edosuyi, Ayobami Adesuyi, Myung Choi, Ighodaro Igbe, Adebayo Oyekan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Osaze EdosuyiDepartment of Pharmacology & Toxicology, Faculty of Pharmacy, University of Benin, PMB 1154, Benin City, Nigeria; Center for Cardiovascular Diseases, Gray Hall Suites, Rm 256, College of Pharmacy & Health Sciences, Texas Southern University, 3100, Cleburne Street, Houston, TX, USA. Electronic address: osaze.edosuyi@uniben.edu.
Ayobami AdesuyiDepartment of Pharmacology & Toxicology, Faculty of Pharmacy, University of Benin, PMB 1154, Benin City, Nigeria; Community Medicine Department, Babcock University Teaching Hospital, IIishan-Remo, Ogun state, Nigeria.
Myung ChoiCenter for Cardiovascular Diseases, Gray Hall Suites, Rm 256, College of Pharmacy & Health Sciences, Texas Southern University, 3100, Cleburne Street, Houston, TX, USA.
Ighodaro IgbeDepartment of Pharmacology & Toxicology, Faculty of Pharmacy, University of Benin, PMB 1154, Benin City, Nigeria.
Adebayo OyekanCenter for Cardiovascular Diseases, Gray Hall Suites, Rm 256, College of Pharmacy & Health Sciences, Texas Southern University, 3100, Cleburne Street, Houston, TX, USA.
Texas Southern University · USBabcock University · NGUniversity of Benin · NG

Funding

Targeted Nano-drug-delivery-systems of Frist-in-class Drugs for CRPC: PK/PD Evaluation and Combination TherapyU54MD007605 · NIMHD · TEXAS SOUTHERN UNIVERSITY · PI Creaque C Tyler · 2020 to 2026
$22.0M
Center for Biomedical and Health Research Excellence (CBHRE)G12MD007605 · NIMHD · TEXAS SOUTHERN UNIVERSITY · PI OYEKAN, ADEBAYO O., WILSON, BOBBY L · 2014 to 2018
$7.1M
NIMHD NIH HHS G12 MD007605NIMHD NIH HHS U54 MD007605
6 · The paper itself

Abstract

Malate regulates blood pressure via nitric oxide production in salt-sensitive rats, a genetic model of hypertension. This study investigated the possible contributions of malate to blood pressure regulation and renal haemodynamics in normotensive rats. Malate (0.1, 0.3 and 1 μg/kg, iv) was injected into rats or L-nitro-arginine methyl ester (L-NAME)-treated rats and mean arterial blood pressure (MABP), cortical blood flow (CBF), and medullary blood flow (MBF), was measured. The clearance study involved infusion of malate at 0.1 μg/kg/h into rats, and MABP, CBF, MBF, glomerular filtration rate (GFR), urine volume (UV) and sodium output (U

Indexed as

Epithelial Sodium ChannelsNitric OxideAmilorideAnimalsBlood PressureHemodynamicsKidneyMalatesNG-Nitroarginine Methyl EsterRatsRenal CirculationSodiumAmilorideEpithelial Sodium ChannelsMalatesmalic acidNG-Nitroarginine Methyl EsterNitric OxideSodiumBlood pressureEpithelial sodium channels (E(Na)C)MalateRenal haemodynamicsSodium excretion

Identifiers

PMID36463945
PMCPMC9772084
OpenAlexW4310525309

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.