Evidence map›Paper›PMID 36463540›Full record

ArticleJournal of clinical monitoring and computing2023

Agreement of somatic and renal near-infrared spectroscopy with reference blood samples during a controlled hypoxia sequence: a healthy volunteer study.

Ilonka N De Keijzer, Dario Massari, Caren K Niezen, Reinoud P H Bokkers, Jaap Jan Vos, Thomas W L Scheeren

2 registry-linked trialsAbstract readControlled Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical monitoring and computing, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04584788 nacompletednot on this map

A Single-Center, Prospective Study in Healthy Volunteers for Validation of the O3 Regional Somatic Tissue Oxygenation Monitor

TypeinterventionalSponsorMasimo CorporationRan2020 to 2021Enrolled37ConditionsOxygen DeficiencyArmsMasimo O3 Regional Oximeter
NCT07339449 narecruitingnot on this mapstarted 2025, after this paper: background citation

Intraoperative Multimodal Monitoring as a Means in Reducing the Duration of Mechanical Ventilation in High-Risk Patients Undergoing Major Abdominal Procedures - A Pilot Study

TypeinterventionalSponsorUniversity Hospital DubravaRan2025 to 2027Enrolled100ConditionsMajor Abdominal Surgeries, Mechanical VentilationArmsMultimodal monitoring
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Observational
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ilonka N De KeijzerDepartment of Anesthesiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. i.n.de.keijzer@umcg.nl.
Dario MassariDepartment of Anesthesiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Caren K NiezenDepartment of Anesthesiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Reinoud P H BokkersDepartment of Radiology, Medical Imaging Center, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Jaap Jan VosDepartment of Anesthesiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Thomas W L ScheerenDepartment of Anesthesiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeO3® Regional Oximetry (Masimo Corporation, California, USA) is validated for cerebral oximetry. We aimed to assess agreement of somatic and renal near-infrared spectroscopy with reference blood samples.

methodsO3 sensors were placed bilaterally on the quadriceps and flank of 26 healthy volunteers. A stepped, controlled hypoxia sequence was performed by adding a mixture of nitrogen and room air to the breathing circuit. O3-derived oxygen saturation values were obtained at baseline and at six decremental saturation levels (5% steps). Blood samples (radial artery, iliac vein (somatic reference) and renal vein) were obtained at each step. Reference values were calculated as: 0.7 × venous saturation + 0.3 × arterial saturation. The agreement between O3-derived values with blood reference values was assessed by calculating root-mean-square error accuracy and Bland-Altman plots.

resultsThe root-mean-square error accuracy was 6.0% between quadriceps oxygen saturation and somatic reference values. The mean bias was 0.8%, with limits of agreement from -7.7 to 9.3%. These were 5.1% and 0.6% (-8.3 to 9.5%) for flank oxygen saturation and somatic reference values, respectively, and 7.7% and -4.9% (-15.0 to 5.2%) for flank oxygen saturation and renal reference values. The kidney depth was 3.1 ± 0.9 cm below the skin.

conclusionO3 regional oximetry can be used on the quadriceps and flank to monitor somatic saturation, yet has a saturation-level dependent bias. O3-derived values obtained at the flank underestimated renal reference values. Additionally, it is unlikely that the flank sensors did directly measure renal tissue.

trial registrationClinicaltrials.gov (NCT04584788): registered October 6th, 2020.

Indexed as

OximetrySpectroscopy, Near-InfraredCerebrovascular CirculationHealthy VolunteersHumansHypoxiaKidneyOxygenOxygenNIRSRegional oximetryRenal oxygen saturationSomatic oxygen saturationTissue oxygenation

Identifiers

PMID36463540
PMCPMC10175462

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.