ArticleJournal of Alzheimer's disease : JAD2023
Increased Functional Connectivity of the Precuneus in Individuals with a Family History of Alzheimer's Disease.
Article in Journal of Alzheimer's disease : JAD, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- Brain activation in older adults during odor identification is related to ApoE, t-tau/AβNeurobiology of aging · 2025Article
- Multimodal MRI accurately identifies amyloid status in unbalanced cohorts in Alzheimer's disease continuum.Network neuroscience (Cambridge, Mass.) · 2025Article
- Alterations of gray matter volume and functional connectivity in patients with cognitive impairment induced by occupational aluminum exposure: a case-control study.Frontiers in neurology · 2024Article
- Antisaccadic eye movements in middle-aged individuals with a family history of Alzheimer's disease.Frontiers in human neuroscience · 2023Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundFirst-degree relatives of individuals with late-onset Alzheimer's disease (AD) have increased risk for AD, with children of affected parents at an especially high risk.
objectiveWe aimed to investigate default mode network connectivity, medial temporal cortex volume, and cognition in cognitively healthy (CH) individuals with (FH+) and without (FH-) a family history of AD, alongside amnestic mild cognitive impairment (aMCI) and AD individuals, to determine the context and directionality of dysfunction in at-risk individuals. Our primary hypothesis was that there would be a linear decline (CH FH- > CH FH+ > aMCI > AD) within the risk groups on all measures of AD risk.
methodsWe used MRI and fMRI to study cognitively healthy individuals (n = 28) with and without AD family history (FH+ and FH-, respectively), those with aMCI (n = 31) and early-stage AD (n = 25). We tested connectivity within the default mode network, as well as measures of volume and thickness within the medial temporal cortex and selected seed regions.
resultsAs expected, we identified decreased medial temporal cortex volumes in the aMCI and AD groups compared to cognitively healthy groups. We also observed patterns of connectivity across risk groups that suggest a nonlinear relationship of change, such that the FH+ group showed increased connectivity compared to the FH- and AD groups (CH FH+ > CH FH- > aMCI > AD). This pattern emerged primarily in connectivity between the precuneus and frontal regions.
conclusionThese results add to a growing literature that suggests compensatory brain function in otherwise cognitively healthy individuals with a family history of AD.
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