Evidence map›Paper›PMID 36463408›Full record

ArticleBiophysical journal2023

New N-aryl-N-alkyl-thiophene-2-carboxamide compound enhances intracellular Ca

Roman Nikolaienko, Elisa Bovo, Samantha L Yuen, Levy M Treinen, Kaja Berg, Courtney C Aldrich, David D Thomas, Razvan L Cornea, Aleksey V Zima

Open access · greenAbstract read
In one paragraph

Article in Biophysical journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Development of activators for SERCA2a for heart failure treatments.European journal of medicinal chemistry · 2026
    Article
  2. Article
  3. Article
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  5. Regulation of cardiac calcium signaling by newly identified calcium pump modulators.Biochemical and biophysical research communications · 2023
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Roman NikolaienkoDepartment of Cell and Molecular Physiology, Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois.
Elisa BovoDepartment of Cell and Molecular Physiology, Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois.
Samantha L YuenDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota.
Levy M TreinenDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota.
Kaja BergDepartment of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota.
Courtney C AldrichDepartment of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota.
David D ThomasDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota.
Razvan L CorneaDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota.
Aleksey V ZimaDepartment of Cell and Molecular Physiology, Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois. Electronic address: azima@luc.edu.
University of Minnesota · USLoyola University Chicago · US

Funding

Structural Dynamics of Cardiac Muscle Calcium ATPase RegulationR01HL139065 · NHLBI · UNIVERSITY OF MINNESOTA · PI Robyn T Rebbeck, David D Thomas · 2020 to 2026
$5.2M
Site-Directed Oxidative Modification of Muscle Protein Structural DynamicsR37AG026160 · NIA · UNIVERSITY OF MINNESOTA · PI THOMAS, DAVID D · 2011 to 2020
$4.5M
High-Throughput Screens to Discover Novel Inhibitors of Leaky RyR2 for Heart Failure TherapyR01HL138539 · NHLBI · UNIVERSITY OF MINNESOTA · PI BERS, DONALD M, CORNEA, RAZVAN LIVIU · 2018 to 2021
$3.1M
New mechanisms of SERCA2a regulation: role of luminal calciumR01HL151990 · NHLBI · LOYOLA UNIVERSITY CHICAGO · PI ZIMA, ALEKSEY V · 2021 to 2024
$1.7M
NHLBI NIH HHS R01 HL138539NHLBI NIH HHS R01 HL139065NHLBI NIH HHS R01 HL151990NIA NIH HHS R37 AG026160
6 · The paper itself

Abstract

The type 2a sarco/endoplasmic reticulum Ca

Indexed as

Heart FailureSarcoplasmic Reticulum Calcium-Transporting ATPasesAnimalsCalciumHEK293 CellsHumansMiceMyocytes, CardiacSarcoplasmic ReticulumThiophenesATP2A2 protein, humanAtp2a2 protein, mouseCalciumSarcoplasmic Reticulum Calcium-Transporting ATPasesThiophenes

Identifiers

PMID36463408
PMCPMC9892616
OpenAlexW4310668705

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.