Evidence map›Paper›PMID 36463347›Full record

ArticleCommunications biology2022

Postsynaptic plasticity of Purkinje cells in mice is determined by molecular identity.

Stijn Voerman, Bastiaan H A Urbanus, Martijn Schonewille, Joshua J White, Chris I De Zeeuw

Open access · goldAbstract read
In one paragraph

Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Stijn Voerman *Department of Neuroscience, Erasmus MC, 3000 DR, Rotterdam, The Netherlands.ORCID 0000-0001-6113-6276
Bastiaan H A Urbanus *Department of Neuroscience, Erasmus MC, 3000 DR, Rotterdam, The Netherlands.
Martijn SchonewilleDepartment of Neuroscience, Erasmus MC, 3000 DR, Rotterdam, The Netherlands.
Joshua J WhiteDepartment of Neuroscience, Erasmus MC, 3000 DR, Rotterdam, The Netherlands.ORCID 0000-0002-6218-623X
Chris I De ZeeuwDepartment of Neuroscience, Erasmus MC, 3000 DR, Rotterdam, The Netherlands. c.dezeeuw@erasmusmc.nl.ORCID 0000-0001-5628-8187
Erasmus MC · NLNetherlands Institute for Neuroscience · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebellar learning is expressed as upbound or downbound changes in simple spike activity of Purkinje cell subpopulations, but the underlying mechanism remains enigmatic. By visualizing murine Purkinje cells with different molecular identities, we demonstrate that the potential for induction of long-term depression is prominent in downbound and minimal in the upbound subpopulation. These differential propensities depend on the expression profile, but not on the synaptic inputs, of the individual Purkinje cell involved, highlighting the functional relevance of intrinsic properties for memory formation.

Indexed as

CerebellumPurkinje CellsAnimalsLearningMiceNeuronal Plasticity

Identifiers

PMID36463347
PMCPMC9719509
OpenAlexW4310775162

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.