Evidence map›Paper›PMID 36463304›Full record

ArticleScientific reports2022

RBDtector: an open-source software to detect REM sleep without atonia according to visual scoring criteria.

Annika Röthenbacher, Matteo Cesari, Christopher E J Doppler, Niels Okkels, Nele Willemsen, Nora Sembowski, Aline Seger, Marie Lindner, Corinna Brune, Ambra Stefani and 6 more

Abstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. The Future of Parasomnias.Journal of sleep research · 2025
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. REM Behavior Disorder: Implications for PD Therapeutics.Current neurology and neuroscience reports · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Annika RöthenbacherInstitute of Neuroscience and Medicine (INM-1), Forschungszentrum Jülich, Jülich, Germany.
Matteo CesariDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Christopher E J DopplerDepartment of Neurology, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Niels OkkelsDepartment of Nuclear Medicine and PET Centre, Aarhus University Hospital, Aarhus, Denmark.
Nele WillemsenDepartment of Neurology, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Nora SembowskiDepartment of Neurology, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Aline SegerDepartment of Neurology, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Marie LindnerDepartment of Neurology, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Corinna BruneDepartment of Neurology, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Ambra StefaniDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Birgit HöglDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Stephan BialonskiDepartment of Medical Engineering and Technomathematics, FH Aachen University of Applied Sciences, Jülich, Germany.
Per BorghammerDepartment of Nuclear Medicine and PET Centre, Aarhus University Hospital, Aarhus, Denmark.
Gereon R FinkDepartment of Neurology, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Martin SchoberInstitute of Neuroscience and Medicine (INM-1), Forschungszentrum Jülich, Jülich, Germany.
Michael SommerauerDepartment of Neurology, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany. m.sommerauer@fz-juelich.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

REM sleep without atonia (RSWA) is a key feature for the diagnosis of rapid eye movement (REM) sleep behaviour disorder (RBD). We introduce RBDtector, a novel open-source software to score RSWA according to established SINBAR visual scoring criteria. We assessed muscle activity of the mentalis, flexor digitorum superficialis (FDS), and anterior tibialis (AT) muscles. RSWA was scored manually as tonic, phasic, and any activity by human scorers as well as using RBDtector in 20 subjects. Subsequently, 174 subjects (72 without RBD and 102 with RBD) were analysed with RBDtector to show the algorithm's applicability. We additionally compared RBDtector estimates to a previously published dataset. RBDtector showed robust conformity with human scorings. The highest congruency was achieved for phasic and any activity of the FDS. Combining mentalis any and FDS any, RBDtector identified RBD subjects with 100% specificity and 96% sensitivity applying a cut-off of 20.6%. Comparable performance was obtained without manual artefact removal. RBD subjects also showed muscle bouts of higher amplitude and longer duration. RBDtector provides estimates of tonic, phasic, and any activity comparable to human scorings. RBDtector, which is freely available, can help identify RBD subjects and provides reliable RSWA metrics.

Indexed as

REM Sleep Behavior DisorderSleep, REMCaffeineFacial MusclesHumansMuscle HypotoniaNiacinamideSoftwareCaffeineNiacinamide

Identifiers

PMID36463304
PMCPMC9719467

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.