Evidence map›Paper›PMID 36463228›Full record

ArticleNPJ vaccines2022

Centrin-deficient Leishmania mexicana confers protection against Old World visceral leishmaniasis.

Subir Karmakar, Greta Volpedo, Wen-Wei Zhang, Patrick Lypaczewski, Nevien Ismail, Fabiano Oliveira, James Oristian, Claudio Meneses, Sreenivas Gannavaram, Shaden Kamhawi and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ vaccines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
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  4. Microorganisms · 2025
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  6. LmCenNPJ vaccines · 2025
    Article
  7. An update on recombinant vaccines against leishmaniasis.The Indian journal of medical research · 2024
    Review
  8. The intersection of hostMicrobiology and molecular biology reviews : MMBR · 2024
    Review
  9. Live attenuated-nonpathogenicFrontiers in microbiology · 2024
    Review
  10. Review
  11. iScience · 2023
    Article
  12. iScience · 2023
    Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 3 countries.

Subir KarmakarDivsion of Emerging and Transfusion Transmitted Diseases, CBER, FDA, Silver Spring, MD, USA.
Greta VolpedoDepartment of Pathology and Microbiology, Ohio State University, Columbus, OH, USA.
Wen-Wei ZhangDepartment of Microbiology and Immunology, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0003-1996-876X
Patrick LypaczewskiDepartment of Microbiology and Immunology, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0002-5550-712X
Nevien IsmailDivsion of Emerging and Transfusion Transmitted Diseases, CBER, FDA, Silver Spring, MD, USA.ORCID http://orcid.org/0000-0003-0294-8834
Fabiano OliveiraVector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD, 20852, USA.ORCID http://orcid.org/0000-0002-7924-8038
James OristianVector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD, 20852, USA.
Claudio MenesesVector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD, 20852, USA.
Sreenivas GannavaramDivsion of Emerging and Transfusion Transmitted Diseases, CBER, FDA, Silver Spring, MD, USA.ORCID http://orcid.org/0000-0002-6557-8220
Shaden KamhawiVector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD, 20852, USA. skamhawi@niaid.nih.gov.ORCID http://orcid.org/0000-0003-4304-636X
Shinjiro HamanoDepartment of Parasitology, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan.ORCID http://orcid.org/0000-0003-3881-8337
Jesus G ValenzuelaVector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD, 20852, USA. jvalenzuela@niaid.nih.gov.ORCID http://orcid.org/0000-0002-5589-9450
Greg MatlashewskiDepartment of Microbiology and Immunology, McGill University, Montreal, QC, Canada. Greg.matlashewski@mcgill.ca.ORCID http://orcid.org/0000-0002-8971-5525
Abhay R SatoskarDepartment of Pathology and Microbiology, Ohio State University, Columbus, OH, USA. Abhay.Satoskar@osumc.edu.ORCID http://orcid.org/0000-0001-5989-1520
Ranadhir DeyDivsion of Emerging and Transfusion Transmitted Diseases, CBER, FDA, Silver Spring, MD, USA. Ranadhir.Dey@fda.hhs.gov.ORCID http://orcid.org/0000-0003-0069-7867
Hira L NakhasiDivsion of Emerging and Transfusion Transmitted Diseases, CBER, FDA, Silver Spring, MD, USA. Hira.Nakhasi@fda.hhs.gov.ORCID http://orcid.org/0000-0003-4941-1620
Vector (United States) · USCenter for Biologics Evaluation and Research · USMcGill University · CAThe Ohio State University · USMcGill Genome Centre · CANagasaki University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Leishmaniasis is one of the top neglected tropical diseases with significant morbidity and mortality in low and middle-income countries (LMIC). However, this disease is also spreading in the developed world. Currently, there is a lack of effective strategies to control this disease. Vaccination can be an effective measure to control leishmaniasis and has the potential to achieve disease elimination. Recently, we have generated centrin gene-deleted new world L. mexicana (LmexCen

Identifiers

PMID36463228
PMCPMC9719514
OpenAlexW4310785106

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.