ArticleBrain, behavior, and immunity2023
Excess body weight and specific types of depressive symptoms: Is there a mediating role of systemic low-grade inflammation?
Article in Brain, behavior, and immunity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 37 citations in OpenAlex.
- The association of multi-system health status and its longitudinal changes with cardiovascular disease risk: insights from a secondary analysis of four multinational cohort studies.Journal of global health · 2026Article
- Joint Effects of Adverse Childhood Experiences and Genetic Burden of Depression on Multiple Depressive Symptoms.Stress and health : journal of the International Society for the Investigation of Stress · 2026Article
- C-Reactive Protein Trajectories by Summary Metric Across the Coronavirus-2019 Period: A 16-Year Interrupted Time-Series Analysis (2008-2023).Diagnostics (Basel, Switzerland) · 2026Article
- Differential associations of cataracts with somatic and cognitive-affective symptoms of depression: longitudinal findings from the English Longitudinal Study of Ageing.International ophthalmology · 2026Article
- Leveraging transdiagnostic genetic liability to psychiatric disorders to dissect clinical outcomes of anorexia nervosa.Molecular psychiatry · 2026Article
- Depressive Symptoms and Risk of Hearing Loss Among Adults Aged 55 Years and Older: A Population-Based Study.Balkan medical journal · 2026Observational
- Longitudinal trajectories of total, cognitive-affective, and somatic depressive symptoms in relation to hip fracture risk: evidence from the HRS and ELSA cohorts.Frontiers in public health · 2026Article
- Prefrontal Structural Asymmetry Mediates Body Mass Index and Treatment Response in Major Depressive Disorder.Depression and anxiety · 2026Article
- Association between depressive symptom and respiratory health in two prospective cohort studies.NPJ primary care respiratory medicine · 2025Article
- Longitudinal trajectories of somatic and cognitive-affective depressive symptoms influence stroke risk across different populations: Three prospective cohort studies.World journal of psychiatry · 2025Article
- C-reactive protein is associated with pain-type somatic symptoms independent of mental health symptoms in adolescents: Evidence from the ALSPAC study.Brain, behavior, & immunity - health · 2025Article
- Persistently high and fluctuating trajectories of total and somatic depressive symptoms increase diabetes risk: Two prospective cohort studies.World journal of diabetes · 2025Article
- Combined lifestyle, childhood trauma and depressive symptoms in adults with subthreshold depression: a prospective cohort study.Epidemiology and psychiatric sciences · 2025Article
- Pathways linking BMI trajectories and mental health in an adult population-based cohort: role of emotional eating and body dissatisfaction.International journal of obesity (2005) · 2025Article
- Systemic inflammation as a mediator in the link between obesity and depression: Evidence from a nationwide cohort study.BMC psychiatry · 2025Article
- Risk of severe obesity development: Examining the role of psychological well-being related measures and sociodemographic factors in two longitudinal UK cohort studies.British journal of health psychology · 2025Article
- Association between body roundness index and sleep disorder: the mediating role of depression.BMC psychiatry · 2025Article
- Prospective longitudinal study of dynamic depressive symptom trajectories and diabetes onset risk in older adults: a 10-year follow-up of the HRS and ELSA cohorts.Frontiers in public health · 2025Article
- The association of eight-year trajectories in total, cognitive-affective, and somatic depressive symptoms with incident stroke: a 10-year follow-up study using HRS and ELSA cohorts.Frontiers in aging neuroscience · 2025Article
- Eight-year total, cognitive-affective, and somatic depressive symptoms trajectories and risks of cardiac events.Translational psychiatry · 2024Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesObesity is associated with an increased risk of depression. Systemic low-grade inflammation, a plausible consequence of obesity, has also been linked to depression. However, the potential mediating effects of systemic low-grade inflammation on the association between excess body weight and specific symptom domains of depression remain uncertain. This study examined whether systemic low-grade inflammation mediated the associations of excess body weight (overweight and obesity) with subsequent overall, cognitive-affective, and somatic depressive symptoms.
designThis study used a prospective cohort design.
methodsThe final analytical sample included 4,942 adults aged ≥50 years drawn from the English Longitudinal Study of Ageing (ELSA). Body mass index (BMI) and covariates were ascertained at baseline (wave 4, 2008/09). Continuous BMI scores were divided into four categories: 'normal weight' (18.5 ≤ BMI <25 kg/m
resultsIn multivariable-adjusted analyses, excess body weight was associated with elevated somatic (OR = 1.231, 95% CI: 1.029, 1.473), but not cognitive-affective or overall depressive symptoms at follow-up. Higher CRP was associated with elevated somatic (OR = 1.156, 95% CI: 1.061, 1.259), but not cognitive-affective or overall depressive symptoms. CRP acted as a partial mediator (14.92%) of the association between excess body weight and elevated somatic, but not cognitive-affective, or overall depressive symptoms.
conclusionSystemic low-grade inflammation may partially explain the association of excess body weight with somatic depressive symptoms, but not the associations with cognitive-affective or overall depressive symptoms.
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