Evidence map›Paper›PMID 36462295›Full record

ArticlePsychoneuroendocrinology2023

Circadian cortisol secretion in adolescent girls with conduct disorder.

Amanda Helleman, Robert T Rubin, William Gardner, Andrea Lourie, Anna N Taylor, Justinn Cochran, Lorah D Dorn, Elizabeth Susman, Nick Barrowman, Vid Bijelić and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychoneuroendocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Amanda HellemanCHEO Research Institute, Ottawa, Ontario, Canada.
Robert T RubinDavid Geffen School of Medicine at UCLA, Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA, USA.
William GardnerCHEO Research Institute, Ottawa, Ontario, Canada; The Research Institute at Nationwide Children's Hospital, The Ohio State University, Department of Pediatrics, Columbus, OH, USA.
Andrea LourieThe Research Institute at Nationwide Children's Hospital, The Ohio State University, Department of Pediatrics, Columbus, OH, USA.
Anna N TaylorDavid Geffen School of Medicine at UCLA, Department of Neurobiology, Los Angeles, CA, USA.
Justinn CochranThe Research Institute at Nationwide Children's Hospital, The Ohio State University, Department of Pediatrics, Columbus, OH, USA.
Lorah D DornCincinnati Children's Hospital Medical Center, Division of Adolescent Medicine, Cincinnati, OH, USA.
Elizabeth SusmanCollege of Health and Human Development, The Pennsylvania State University, University Park, PA, USA.
Nick BarrowmanCHEO Research Institute, Ottawa, Ontario, Canada.
Vid BijelićCHEO Research Institute, Ottawa, Ontario, Canada.
Lisa LeiningerThe Research Institute at Nationwide Children's Hospital, The Ohio State University, Department of Pediatrics, Columbus, OH, USA.
Kathleen PajerCHEO Research Institute, Ottawa, Ontario, Canada; The Research Institute at Nationwide Children's Hospital, The Ohio State University, Department of Pediatrics, Columbus, OH, USA. Electronic address: kpajer@cheo.on.ca.
Agricultural Research Institute of Ontario · CACincinnati Children's Hospital Medical Center · USNeurobehavioral Systems · USPennsylvania State University · USUniversity of California, Los Angeles · US

Funding

YOGA, IMMUNE FUNCTION, AND HEALTHM01RR000034 · NCRR · OHIO STATE UNIVERSITY · PI PASKETT, ELECTRA D. · 1985 to 2008
$22.7M
HPA Axis Function in Adolescent Antisocial FemalesR01MH066003 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PAJER, KATHLEEN ANN · 2003 to 2007
$1.9M
NCRR NIH HHS M01 RR000034NIMH NIH HHS R01 MH066003
6 · The paper itself

Abstract

Severe antisocial behavior in girls, best exemplified by conduct disorder (CD), is a serious clinical and public health problem. Treatment is difficult, particularly in girls with comorbid internalizing disorders. Identifying biological correlates may help to develop new treatments or diagnostic, prognostic, or treatment response biomarkers. Based on our earlier work and research from others occurring primarily in boys with severe antisocial behavior, it is possible that abnormalities in the hypothalamic pituitary adrenal (HPA) axis circadian cortisol cycle may be associated with female CD. Additionally, research suggests that the presence of comorbid internalizing disorders may be related to differences in cortisol secretion, compared to subjects who only have CD. Our study aimed: 1) to compare the circadian cortisol cycle in 98 girls with CD, 15-16 years of age to 47 girls without any psychiatric disorder (ND) and 2) to compare the cycle in girls with CD and comorbid internalizing disorders (CD + INT) to those without such comorbidity (CD Only). Salivary cortisol was collected over 24 h during weekdays at scheduled times, with protocol adherence measures in place. Unstructured covariance pattern modeling, controlling for effects of age, social class, IQ, and awakening time was used to analyze cortisol data. CD was associated with overall lower cortisol secretion (p = 0.03), but this difference was due to a lower volume of cortisol secreted 30 min after awakening (area under the curve with respect to ground, p = 0.01). Circadian cortisol secretion was no different in the CD+INT group compared to the CD Only group (p = 0.52). Our findings need to be replicated using current consensus guidelines for the assessment of the CAR. We also suggest two new avenues of research in this field.

Indexed as

Conduct DisorderAdolescentAntisocial Personality DisorderCircadian RhythmFemaleHumansHydrocortisoneHypothalamo-Hypophyseal SystemMaleMiddle AgedPituitary-Adrenal SystemSalivaHydrocortisoneAdolescentsCircadian cortisolConduct disorderGirlsHPA axis

Identifiers

PMID36462295
PMCPMC10038075
OpenAlexW4308979884

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.