Evidence map›Paper›PMID 36462182›Full record

Trial reportInternational journal of geriatric psychiatry2023

Effect of vitamin D supplementation on depression in older Australian adults.

Sabbir T Rahman, Mary Waterhouse, Briony Duarte Romero, Catherine Baxter, Dallas R English, Osvaldo P Almeida, Michael Berk, Peter R Ebeling, Bruce K Armstrong, Donald S A McLeod and 9 more

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International journal of geriatric psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Effect of vitamin D supplementation on depression in older Australian adults.International journal of geriatric psychiatry · 2023
    Trial
  4. Article
  5. Vitamin D and Vitamin BDiseases (Basel, Switzerland) · 2026
    Review
  6. Review
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 9 institutions in 1 country.

Sabbir T RahmanPopulation Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID 0000-0003-3663-6548
Mary WaterhousePopulation Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Briony Duarte RomeroPopulation Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Catherine BaxterPopulation Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Dallas R EnglishMelbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.
Osvaldo P AlmeidaMedical School, University of Western Australia, Perth, Western Australia, Australia.ORCID 0000-0002-8689-6199
Michael BerkDeakin University, Institute for Mental and Physical Health and Clinical Translation (IMPACT), Barwon Health, Geelong, Victoria, Australia.
Peter R EbelingDepartment of Medicine, School of Clinical Sciences, Monash University, Melbourne, Victoria, Australia.
Bruce K ArmstrongSchool of Public Health, University of Sydney, Sydney, New South Wales, Australia.
Donald S A McLeodPopulation Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Gunter HartelPopulation Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Rachel L O'ConnellNHMRC Clinical Trials Centre, University of Sydney, Sydney, New South Wales, Australia.
Hai PhamPopulation Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
James G ScottPopulation Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Jolieke C van der PolsQueensland University of Technology (QUT), Faculty of Health, School of Exercise and Nutrition Sciences, Brisbane, Queensland, Australia.
Alison J VennMenzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
Penelope M WebbPopulation Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
David C WhitemanPopulation Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Rachel E NealePopulation Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
QIMR Berghofer Medical Research Institute · AUQueensland Health · AUThe University of Sydney · AUBarwon Health · AUMonash University · AUQueensland University of Technology · AUThe University of Melbourne · AUThe University of Western Australia · AUUniversity of Tasmania · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate whether vitamin D supplementation reduces depressive symptoms and incidence of antidepressant use.

methodsWe used data from the D-Health Trial (N = 21,315), a randomized double-blind placebo-controlled trial of monthly vitamin D

resultsAnalyses of PHQ-9 scores included 20,487 participants (mean age 69·3 years, 46% women); the mean difference (MD) in PHQ-9 score (vitamin D vs. placebo) was 0·02 (95% CI -0·06, 0·11). There was negligible difference in the prevalence of clinically relevant depression (PHQ-9 score ≥10) (odds ratio 0·99; 95% CI 0·90, 1·08). We included 16,670 participants in the analyses of incident antidepressant use (mean age 69·4 years, 43% women). Incidence of antidepressant use was similar between the groups (hazard ratio [HR] 1·04; 95% CI 0·96, 1·12). In subgroup analyses, vitamin D improved PHQ-9 scores in those taking antidepressants at baseline (MD -0·25; 95% CI -0·49, -0·01; p-interaction = 0·02). It decreased risk of antidepressant use in participants with predicted 25(OH)D concentration <50 nmol/L (HR 0·88; 95% CI 0·75, 1·02; p-interaction = 0·01) and increased risk in those with predicted 25(OH)D ≥ 50 nmol/L (HR 1·10; 95% CI 1·01, 1·20).

conclusionMonthly supplementation with high-dose vitamin D CLINICAL

trial registrationThe trial is registered on the Australian New Zealand Clinical Trials Registry: ACTRN12613000743763. https://www.anzctr.org.au/.

Indexed as

DepressionDietary SupplementsAgedAustraliaCholecalciferolDouble-Blind MethodFemaleHumansMaleVitamin DVitaminsCholecalciferolVitamin DVitaminsantidepressantsdepressionmental disordersPHQ-9preventionrandomized controlled trialvitamin D supplementation

Identifiers

PMID36462182
PMCPMC10108111
OpenAlexW4309778902

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.