Evidence map›Paper›PMID 36462128›Full record

ArticleGeroScience2023

Morusin and mulberrin extend the lifespans of yeast and C. elegans via suppressing nutrient-sensing pathways.

Pingkang Xu, Qimin Chen, Xiaoman Chen, Hao Qi, Yuyan Yang, Weiqi Li, Xin Yang, Amelia Gunawan, Shuoyu Chen, Huimin Zhang and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Advanced Oral Delivery Systems for Nutraceuticals.Advanced healthcare materials · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 3 countries.

Pingkang Xu *Department of Food Science and Technology, National University of Singapore, 2 Science Drive 2, Singapore, 117542, Singapore.
Qimin Chen *Department of Food Science and Technology, National University of Singapore, 2 Science Drive 2, Singapore, 117542, Singapore.
Xiaoman ChenDepartment of Food Science and Technology, National University of Singapore, 2 Science Drive 2, Singapore, 117542, Singapore.
Hao QiDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Yuyan YangJiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China.
Weiqi LiDepartment of Food Science and Technology, National University of Singapore, 2 Science Drive 2, Singapore, 117542, Singapore.
Xin YangDepartment of Food Science and Technology, National University of Singapore, 2 Science Drive 2, Singapore, 117542, Singapore.
Amelia GunawanDepartment of Food Science and Technology, National University of Singapore, 2 Science Drive 2, Singapore, 117542, Singapore.
Shuoyu ChenDepartment of Food Science and Technology, National University of Singapore, 2 Science Drive 2, Singapore, 117542, Singapore.
Huimin ZhangJiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China.
Han-Ming ShenDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Dejian HuangDepartment of Food Science and Technology, National University of Singapore, 2 Science Drive 2, Singapore, 117542, Singapore. dejian@nus.edu.sg.ORCID http://orcid.org/0000-0002-2305-3960
Brian KennedyHealthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. bkennedy@nus.edu.sg.
Li XuState Key Laboratory of Silkworm Genome Biology, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing, 400716, China. mulberry@swu.edu.cn.
Ziyun WuDepartment of Food Science and Engineering, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China. wuziyun@sjtu.edu.cn.
National University of Singapore · SGSoochow University · CNShanghai Jiao Tong University · CNSouthwest University · CN

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
NIH HHS P40 OD010440
6 · The paper itself

Abstract

Compounds with lifespan extension activity are rare, although increasing research efforts have been invested in this field to find ways to extend healthy lifespan. By applying a yeast-based high-throughput assay to identify the chronological lifespan extension activity of mulberry extracts rapidly, we demonstrated that a group of prenylated flavones, particularly morusin and mulberrin, could extend the chronological lifespan of budding yeast via a nutrient-dependent regime by at least partially targeting SCH9. Their antiaging activity could be extended to C. elegans by promoting its longevity, dependent on the full functions of genes akt-1 or akt-2. Moreover, additional benefits were observed from morusin- and mulberrin-treated worms, including increased reproduction without the influence of worm health (pumping rate, pumping decline, and reproduction span). In the human HeLa cell model, morusin and mulberrin inhibited the phosphorylation of p70S6K1, promoted autophagy, and slowed cell senescence. The molecular docking study showed that mulberrin and morusin bind to the same pocket of p70S6K1. Collectively, our findings open up a potential class of prenylated flavones performing their antiaging activity via nutrient-sensing pathways.

Indexed as

FlavonesLongevityAnimalsBenzene DerivativesCaenorhabditis elegansFlavonoidsHeLa CellsHumansMolecular Docking SimulationProto-Oncogene Proteins c-aktSaccharomyces cerevisiaeBenzene DerivativesFlavonesFlavonoidsmorusinMulberrinProto-Oncogene Proteins c-aktAntiagingmTOR/S6K1MulberryPrenylated flavonoidsStructure–activity relationship

Identifiers

PMID36462128
PMCPMC9886792
OpenAlexW4310639157

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.