ArticleEuropean radiology2023
Tanner-Whitehouse skeletal maturity score derived from ultrasound images to evaluate bone age.
Article in European radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Ultrasonography is a reliable clinical method for assessing biological maturation.BMC sports science, medicine & rehabilitation · 2026Article
- Brain tissue biomarker impact bone age in central precocious puberty more than hormones: a quantitative synthetic magnetic resonance study.Japanese journal of radiology · 2025Article
- Advances in Musculoskeletal Ultrasound for Assistive Diagnosis in Pain Clinics.Pain and therapy · 2025Review
- Assessment of Biological Age With Conventional Ultrasound Imaging as an Alternative to X-Ray-A Pilot Study in Youth Soccer.European journal of sport science · 2025Article
- Enhancing Pediatric Bone Age Assessment Using Artificial Intelligence: Implications for Orthopedic Surgery.Cureus · 2025Article
- Bone Age Assessment Using Various Medical Imaging Techniques Enhanced by Artificial Intelligence.Diagnostics (Basel, Switzerland) · 2025Review
- Ultrasound-based bone age assessment in children and adolescents: a mini-review.Frontiers in pediatrics · 2025Review
- Reliability of Two Recently Developed Procedures Assessing Biological Maturity by Ultrasound Imaging-A Pilot Study.Children (Basel, Switzerland) · 2024Article
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2 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe complexity of radiographic Tanner-Whitehouse method makes it less acceptable by radiologists and endocrinologists to assess bone age. Conventional ultrasound could be used to measure the ratio of the height of the ossification center to the epiphysis of the bone to evaluate maturity of bone. The purpose of this study is to obtain radiographic TW3 skeletal maturity score with ultrasound images.
methodsIn this prospective diagnostic study, participants aged between 1 and 18 years undergoing radiography for bone age evaluation were evaluated from April 2019 to November 2021. Ultrasonic skeletal maturity scores of participants were transformed into radiographic skeletal maturity scores with the fitted formulas established in this study. Diagnostic performances of the transformed scores to diagnose advanced or delayed bone age were confirmed. Ultrasound images of 50 participants in the validation group were re-evaluated to confirm inter-rater reliability.
resultsA total of 442 participants (median age, 9.5 years [interquartile range, 7.8-11.1 years]; 185 boys) were enrolled. Ultrasound determination of bone age had a sensitivity of 97% (34/35, 95% CI: 83, 99) and a specificity of 98% (106/108, 95% CI: 93, 99) to diagnose advanced or delayed bone age. The intra-class correlation coefficient for inter-rater reliability was 0.993 [95% CI: 0.988, 0.996], p < 0.0001.
conclusionsRadiographic Tanner-Whitehouse skeletal maturity score could be obtained from ultrasound images in a simple, fast, accurate, and radiation-free manner. KEY POINTS: • The fitting formulas between radiographic TW3 skeletal maturity score and ultrasonic skeletal maturity score were developed. • Through measurement of ossification ratios of bones with ultrasound, TW3 skeletal maturity score was obtained in a simple, fast, and radiation-free manner.
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