ArticleLaboratory animal research2022
Resistance exercise training-induced skeletal muscle strength provides protective effects on high-fat-diet-induced metabolic stress in mice.
Article in Laboratory animal research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 8 citations in OpenAlex.
- Energy Substrate Utilization and Body Composition Following Exercise Preconditioning During Alternate-Day Fasting and Concurrent Exercise in Mice.Metabolites · 2026Article
- Exercise Improves Sarcopenic Obesity Through Inhibition of Ferroptosis and Activation of the AMPK/ACC Pathway.International journal of molecular sciences · 2026Article
- Effects of Swimming at Different Water Temperatures on Muscle and Adipose Tissue Adaptation in Diet-Induced Obese Mice.International journal of medical sciences · 2026Article
- Effects of habitual endurance and resistance exercise on insulin action in primary human skeletal muscle stem cells.Physiological reports · 2025Article
- Animal Models of Exercise and Cardiometabolic Disease.Circulation research · 2025Review
- Skeletal muscle growth to combat diabetes and obesity: the potential role of muscle-secreted factors.Obesity (Silver Spring, Md.) · 2025Review
- Extracellular fluid volume as a key indicator in home-care management of chronic heart failure: The role of nutritional and exercise therapy.Clinical case reports · 2024Article
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Authors and funding
4 authors at 1 institution in 4 countries.
Funding
Abstract
backgroundResistance exercise training is known to improve metabolic disorders, such as obesity and type2 diabetes. In this study, we investigated whether the beneficial effects of resistance exercise training persisted even after the discontinuation of training with high-fat diet (HFD)-induced metabolic stress. We further evaluated whether the improvement in skeletal muscle strength and endurance by training were correlated with improved metabolism. Eight-week-old male C57BL/6N mice were divided into groups that remained sedentary or had access to daily resistance exercise via ladder climbing for 8 weeks. Trained and untrained mice were fed an HFD for 1 week after the exercise training intervention (n = 5-8 per group).
resultsResistance exercise-trained mice had a lean phenotype and counteracted diet-induced obesity and glucose tolerance, even after exercise cessation. Grip strength was significantly inversely correlated with the body weight, fat mass, and glucose tolerance. However, hanging time was significantly inversely correlated with body weight only.
conclusionsThese results have strong implications for the preventive effect of resistance exercise-induced metabolic improvement by enhancing skeletal muscle strength rather than endurance.
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