Evidence map›Paper›PMID 36461051›Full record

ArticleBMC musculoskeletal disorders2022

A comparative study of bone union and nonunion during distraction osteogenesis.

Qi Liu, Ze Liu, Hongbin Guo, Min Wang, Jieyu Liang, Yi Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC musculoskeletal disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Qi LiuDepartment of Orthopaedics, Xiangya Hospital, Central South University, Hunan Province, 410008, Changsha, China.
Ze LiuDepartment of Orthopaedics, Xiangya Hospital, Central South University, Hunan Province, 410008, Changsha, China.
Hongbin GuoDepartment of Orthopaedics, Xiangya Hospital, Central South University, Hunan Province, 410008, Changsha, China.
Min WangDepartment of Endocrinology, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
Jieyu LiangDepartment of Orthopaedics, Xiangya Hospital, Central South University, Hunan Province, 410008, Changsha, China. jamesliang8@aliyun.com.
Yi ZhangDepartment of Orthopaedics, Xiangya Hospital, Central South University, Hunan Province, 410008, Changsha, China. zhangyi0205@csu.edu.cn.
Central South University · CNXiangya Hospital Central South University · CN

Funding

Fund of Reform and Practice of Ideological and Political in Xiangya Hospital, Central South University 36Fund of Reform and Practice of Ideological and Political in Xiangya Hospital, Central South University 40FuQing Postdoc Program of Xiangya Hospital, Central South University 176National Outstanding Youth Science Fund Project of National Natural Science Foundation of China 82102581National Postdoctoral Science Foundation of China 2021M693562Provincial Natural Science Foundation of Hunan 2019JJ40517Provincial Natural Science Foundation of Hunan 2022JJ40843Provincial Outstanding Postdoctoral Innovative Talents Program of Hunan 2021RC2020Young Investigator Grant of Xiangya Hospital, Central South University 2020Q14
6 · The paper itself

Abstract

backgroundThe clinical characteristics of bone nonunion during distraction osteogenesis (DO) were rarely discussed. This study was employed to specify the difference between bone union and nonunion during DO.

methodsThe patients with bone lengthening were recruited in our study. The bone union cases indicated the ones that remove the external fixator successfully, whereas the bone nonunion represented the bridging callus did not appear even after 9 months (an absence of bridging callus for at least three out of four cortices on plain radiographs) that needs autogenous bone transplantation. The differences in the pixel value ratio (PVR) growth of regenerated callus, lengthening index (LI), healing index (HI), external fixation index (EFI) and blood biochemical indexes between bone union and nonunion were analyzed.

resultsA total of 8 bone nonunion and 27 bone union subjects were included in this study. The PVR growth in bone nonunion was significantly lower than that in bone union (0.19 ± 0.06 vs. 0.32 ± 0.16, P = 0.048). Interestingly, the HI and EFI in bone nonunion was significantly higher than that in bone union (62.0 ± 31.4 vs. 37.0 ± 27.4, P = 0.036; 75.0 ± 30.9 vs. 49.9 ± 16.1, P = 0.006). However, no significant difference with regard to LI was identified (0.76 ± 0.52 vs. 0.77 ± 0.32, P = 0.976). Moreover, the circulating level of urea and lymphocyte count in bone union was significantly lower than that in bone nonunion (4.31 ± 1.05 vs. 5.17 ± 1.06, P = 0.049; 2.08 ± 0.67 vs. 2.73 ± 0.54, P = 0.018). On the contrary, the circulating level of magnesium in bone union was significantly higher than that in bone nonunion (0.87 ± 0.07 vs. 0.80 ± 0.07, P = 0.014).

conclusionCompared to the bone union, the PVR growth was significantly lower, whereas the HI and EFI was significantly higher in the bone nonunion. Moreover, the circulating level of urea, magnesium and lymphocyte count was also different between these two. Therefore, the PVR, HI and EFI seems to be reliable and sensitive indicators to reflect the bone nonunion during DO, which might be considered in bone lengthening. Further prospective studies are still needed to elaborate the concerned issues.

Indexed as

Osteogenesis, DistractionExternal FixatorsHumansJointsMagnesiumWound HealingMagnesiumBiochemical indexBone union and nonunionDistraction osteogenesisExternal fixatorExternal fixator indexHealing indexLengthening indexPixel value ratio

Identifiers

PMID36461051
PMCPMC9719176
OpenAlexW4310787475

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.