ArticleMolecular psychiatry2023
Frequency dependent emotion differentiation and directional coupling in amygdala, orbitofrontal and medial prefrontal cortex network with intracranial recordings.
Article in Molecular psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Characterization of neural networks involved in transdiagnostic emotion dysregulation from a pilot randomized controlled trial of a neurostimulation-enhanced behavioral intervention.Psychiatry research. Neuroimaging · 2024Trial
- Adaptive shifts in amygdala-hippocampal theta coupling govern aversive learning and extinction.Nature communications · 2026Article
- Detrended fluctuation analysis of amygdala-hippocampal beta synchrony reveals network rigidity in depression associated with temporal lobe epilepsy.Journal of neural engineering · 2026Article
- Habitual Aerobic Exercise Is Associated with Reduced Negative Emotional Elicitation: An fNIRS Study.Brain sciences · 2026Article
- Acupuncture Modulates Neurotransmitter-Related Molecules in the Amygdala to Ameliorate Generalized Anxiety Disorder.CNS neuroscience & therapeutics · 2026Article
- High-definition tDCS regulate the prefrontal-limbic-striatal connectivity and reduce depression in youth with first-episode depression.BMC psychiatry · 2026Article
- Mapping EEG Metrics to Human Affective and Cognitive Models: An Interdisciplinary Scoping Review from a Cognitive Neuroscience Perspective.Biomimetics (Basel, Switzerland) · 2025Review
- Beta bursts mediate amygdala gating of hippocampal emotional encoding.bioRxiv : the preprint server for biology · 2025Article
- Magnetic-Driven Torque-Induced Electrical Stimulation for Millisecond-Scale Wireless Neuromodulation.Advanced healthcare materials · 2025Article
- Intracranial Recordings in Epilepsy: an Approach to Understanding the Neural Mechanisms of Social Cognition.Current neurology and neuroscience reports · 2025Review
- Brain network alterations in mobile phone use problem severity: A multimodal neuroimaging analysis.Journal of behavioral addictions · 2025Article
- Serotonin transporter knockout in rats reduces beta- and gamma-band functional connectivity between the orbitofrontal cortex and amygdala during auditory discrimination.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Associations Between Temporomandibular Disorders and Brain Imaging-Derived Phenotypes.International dental journal · 2024Article
- Abnormal intrinsic functional hubs and connectivity in patients with post-stroke depression.Annals of clinical and translational neurology · 2024Article
- Aerobic exercise promotes emotion regulation: a narrative review.Experimental brain research · 2024Review
- Time-locked acute alpha-frequency stimulation of subthalamic nuclei during the evaluation of emotional stimuli and its effect on power modulation.Frontiers in human neuroscience · 2023Article
- Oscillatory and gaze signatures of socio-emotional speech processing, visuo-spatial cognition, and their interaction in a near-realistic dual-task MEG study.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
The amygdala, orbitofrontal cortex (OFC) and medial prefrontal cortex (mPFC) form a crucial part of the emotion circuit, yet their emotion induced responses and interactions have been poorly investigated with direct intracranial recordings. Such high-fidelity signals can uncover precise spectral dynamics and frequency differences in valence processing allowing novel insights on neuromodulation. Here, leveraging the unique spatio-temporal advantages of intracranial electroencephalography (iEEG) from a cohort of 35 patients with intractable epilepsy (with 71 contacts in amygdala, 31 in OFC and 43 in mPFC), we assessed the spectral dynamics and interactions between the amygdala, OFC and mPFC during an emotional picture viewing task. Task induced activity showed greater broadband gamma activity in the negative condition compared to positive condition in all the three regions. Similarly, beta activity was increased in the negative condition in the amygdala and OFC while decreased in mPFC. Furthermore, beta activity of amygdala showed significant negative association with valence ratings. Critically, model-based computational analyses revealed unidirectional connectivity from mPFC to the amygdala and bidirectional communication between OFC-amygdala and OFC-mPFC. Our findings provide direct neurophysiological evidence for a much-posited model of top-down influence of mPFC over amygdala and a bidirectional influence between OFC and the amygdala. Altogether, in a relatively large sample size with human intracranial neuronal recordings, we highlight valence-dependent spectral dynamics and dyadic coupling within the amygdala-mPFC-OFC network with implications for potential targeted neuromodulation in emotion processing.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.