ArticleNature communications2022
TRPC channels blockade abolishes endotoxemic cardiac dysfunction by hampering intracellular inflammation and Ca
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- The Role of TRP Channels in Colitis and Inflammatory Bowel Disease: A Systematic Review.International journal of molecular sciences · 2025Pooled it
- Ion-GPS nanocapsules activate calcium-permeable gates in inflammatory microglia for nerve function recovery.Bioactive materials · 2026Article
- TRPC6 loss triggers mitochondrial dysfunction that drives white adipose tissue vulnerability to obesity and insulin resistance.Experimental & molecular medicine · 2026Article
- Magnetic Reprogramming of Macrophages Stimulates Phagocytosis of Breast Cancer Cells via a TRPC1-STING Inflammatory Axis.Smart medicine · 2026Article
- Review
- Mortality trends in older adults (55-84 years) with sepsis-atrial fibrillation: a CDC database analysis.BMC public health · 2026Article
- Review
- Spacio-Linear Screening for Ligand-Docking Cavities in Protein Structures: SLAM Algorithm.Life (Basel, Switzerland) · 2026Article
- Taurine Alleviates Sepsis-Induced Myocardial Injury by Inhibiting NF-κB Pathway-Mediated Inflammation, Mitochondrial Dysfunction, and Apoptosis.Cardiovascular toxicology · 2026Article
- Transient receptor potential canonical 3 is required for HPV-induced malignant transformation of cervical epithelial cells.Communications biology · 2026Article
- MG53 protects against septic cardiac dysfunction by ubiquitinating ATF2.Journal of advanced research · 2026Article
- Talin1 modulates the Piezo1-YAP axis to regulate endothelial cell inflammation and atherosclerosis.Cellular and molecular life sciences : CMLS · 2025Article
- α-Linolenic Acid Alleviates Diabetic Cardiomyopathy by Activating AMPK-STAT3 Pathway to Inhibit Ferritinophagy and Enhance SLC7A11-GPX4 Antioxidant Axis.Molecules (Basel, Switzerland) · 2025Article
- Propofol in combination with salvianolic acid A protect against lipopolysaccharide-induced cardiac dysfunction and ferroptosis through activating the SIRT1/FoxO1 signaling under diabetic condition.Annals of medicine · 2025Article
- Physiological functions and pharmacological targeting of transient receptor potential channels.Pharmacological reviews · 2025Review
- Transient receptor potential channels in viral infectious diseases: Biological characteristics and regulatory mechanisms.Journal of advanced research · 2025Review
- A Chimeric Peptide Derived from a Bacterial Effector Protein Attenuates TLR-2/4-Mediated Production of Pro-Inflammatory Cytokines and Enhances the Cellular Availability of Gentamicin.Journal of inflammation research · 2025Article
- Unlocking the potential of cardiac TRP channels using knockout mice models.Frontiers in physiology · 2025Article
- Advances in neutrophil extracellular traps and ferroptosis in sepsis-induced cardiomyopathy.Frontiers in immunology · 2025Review
- Autophagy-driven lipid regulation by an herbal decoction alleviates cardiac lipotoxicity in severe acute pancreatitis.Theranostics · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 6 institutions in 1 country.
Na Tang *Department of Pharmacy, School of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, China.
Wen Tian *Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi'an, Shaanxi, China.
Guang-Yuan Ma *Department of Pharmacy, School of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, China.
Xiong Xiao *Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi'an, Shaanxi, China.
Lei ZhouDepartment of Pharmacy, School of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, China.
Ze-Zhi LiDepartment of Pharmacy, School of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, China.
Xiao-Xiao LiuDepartment of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi'an, Shaanxi, China.
Chong-Yao LiDepartment of Pharmacy, Xi'an No.3 Hospital, the Affiliated Hospital of Northwest University, Xi'an, Shaanxi, China.
Ke-Han WuDepartment of Pharmacy, School of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, China.
Wenjuan LiuDepartment of Pharmacy, School of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, China.
Xue-Ying WangDepartment of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi'an, Shaanxi, China.
Yuan-Yuan GaoDepartment of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi'an, Shaanxi, China.
Xin YangDepartment of Pharmacy, School of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, China.
Jianzhao QiShaanxi Key Laboratory of Natural Products & Chemical Biology, Northwest A&F University, Yangling, Shaanxi, China.ORCID 0000-0003-1418-873X
Ding LiShaanxi Key Laboratory of Natural Products & Chemical Biology, Northwest A&F University, Yangling, Shaanxi, China.
Yang LiuDepartment of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
Wen-Sheng ChenDepartment of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
Jinming GaoDepartment of Pharmacy, School of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, China.
Xiao-Qiang LiDepartment of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi'an, Shaanxi, China. xxqqli@fmmu.edu.cn.ORCID 0000-0003-2463-8298
Wei CaoDepartment of Pharmacy, School of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, China. caowei@nwafu.edu.cn.ORCID 0000-0003-3863-137X
Northwest A&F University · CNState Administration of Traditional Chinese Medicine of the People's Republic of China · CNXijing Hospital · CNAir Force Medical University · CNNorth West Agriculture and Forestry University · CNNorthwest University · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intracellular Ca
Indexed as
Craniocerebral TraumaEndotoxemiaHeart FailureTransient Receptor Potential ChannelsAnimalsInflammationLipopolysaccharidesMiceToll-Like Receptor 4TRPC6 Cation ChannelLipopolysaccharidesToll-Like Receptor 4Transient Receptor Potential ChannelsTRPC6 Cation Channel
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.