Evidence map›Paper›PMID 36460627›Full record

ArticleESC heart failure2023

How does age affect outcomes after left ventricular assist device implantation: results from the PCHF-VAD registry.

Sumant P Radhoe, Jesse F Veenis, Nina Jakus, Philippe Timmermans, Anne-Catherine Pouleur, Pawel Rubís, Emeline M Van Craenenbroeck, Edvinas Gaizauskas, Eduardo Barge-Caballero, Stefania Paolillo and 18 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ESC heart failure, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 15 institutions in 11 countries.

Sumant P RadhoeDepartment of Cardiology, Thorax Center, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID 0000-0002-1070-6715
Jesse F VeenisDepartment of Cardiology, Thorax Center, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Nina JakusDepartment of Cardiovascular Diseases, University of Zagreb School of Medicine and University Hospital Center Zagreb, Zagreb, Croatia.
Philippe TimmermansDepartment of Cardiology, University Hospital Leuven, Leuven, Belgium.
Anne-Catherine PouleurDivision of Cardiology, Department of Cardiovascular Diseases, Cliniques Universitaires St. Luc, Brussels, Belgium.
Pawel RubísDepartment of Cardiac and Vascular Diseases Krakow, Jagiellonian University Medical College, John Paul II Hospital, Krakow, Poland.
Emeline M Van CraenenbroeckAntwerp University Hospital, Antwerp, Belgium.
Edvinas GaizauskasClinic of Cardiac and Vascular Diseases, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
Eduardo Barge-CaballeroINIBIC, CIBERCV, Complejo Hospitalario Universitario de A Coruña, A Coruña, Spain.
Stefania PaolilloDepartment of Advanced Biomedical Sciences, Federico II University of Naples, Naples, Italy.
Sebastian GrundmannFaculty of Medicine, Heart Center Freiburg University, University of Freiburg, Freiburg, Germany.
Domenico D'AmarioFondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Oscar Ö BraunDepartment of Cardiology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden.
Aggeliki GkouzioutaOnassis Cardiac Surgery Centre, Athens, Greece.
Ivo PlanincDepartment of Cardiovascular Diseases, University of Zagreb School of Medicine and University Hospital Center Zagreb, Zagreb, Croatia.
Jure SamardzicDepartment of Cardiovascular Diseases, University of Zagreb School of Medicine and University Hospital Center Zagreb, Zagreb, Croatia.
Bart MeynsDepartment of Cardiac Surgery, University Hospital Leuven, Leuven, Belgium.
Walter DroogneDepartment of Cardiology, University Hospital Leuven, Leuven, Belgium.
Karol WierzbickiDepartment of Cardiovascular Surgery and Transplantology, Institute of Cardiology, Jagiellonian University Medical College, John Paul II Hospital, Krakow, Poland.
Katarzyna HolcmanDepartment of Cardiac and Vascular Diseases Krakow, Jagiellonian University Medical College, John Paul II Hospital, Krakow, Poland.
Andreas J FlammerClinic for Cardiology, University Hospital Zurich, Zurich, Switzerland.
Hrvoje GasparovicDepartment of Cardiac Surgery, University of Zagreb School of Medicine and University Hospital Center Zagreb, Zagreb, Croatia.
Bojan BiocinaDepartment of Cardiac Surgery, University of Zagreb School of Medicine and University Hospital Center Zagreb, Zagreb, Croatia.
Lars H LundDepartment of Medicine, Karolinska Institute, Stockholm, Sweden.
Davor MilicicDepartment of Cardiovascular Diseases, University of Zagreb School of Medicine and University Hospital Center Zagreb, Zagreb, Croatia.
Frank RuschitzkaClinic for Cardiology, University Hospital Zurich, Zurich, Switzerland.
Maja CikesDepartment of Cardiovascular Diseases, University of Zagreb School of Medicine and University Hospital Center Zagreb, Zagreb, Croatia.
Jasper J BrugtsDepartment of Cardiology, Thorax Center, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
University Hospital Centre Zagreb · HRErasmus MC · NLJagiellonian University · PLKU Leuven · BEUniversity Hospital of Zurich · CHAgostino Gemelli University Polyclinic · ITAntwerp University Hospital · BECentro de Investigación Biomédica en Red · ESCliniques Universitaires Saint-Luc · BEKarolinska Institutet · SELund University · SEOnassis Cardiac Surgery Center · GRUniversity of Freiburg · DEUniversity of Naples Federico II · ITVilnius University · LT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsUse of left ventricular assist devices (LVADs) in older patients has increased, and assessing outcomes in older LVAD recipients is important. Therefore, this study aimed to investigate associations between age and outcomes after continuous-flow LVAD (cf-LVAD) implantation. METHODS AND

resultsCf-LVAD patients from the multicentre European PCHF-VAD registry were included and categorized into those <50, 50-64, and ≥65 years old. The primary endpoint was all-cause mortality. Among secondary outcomes were heart failure (HF) hospitalizations, right ventricular (RV) failure, haemocompatibility score, bleeding events, non-fatal thromboembolic events, and device-related infections. Of 562 patients, 184 (32.7%) were <50, 305 (54.3%) were aged 50-64, whereas 73 (13.0%) were ≥65 years old. Median follow-up was 1.1 years. Patients in the oldest age group were significantly more often designated as destination therapy (DT) candidates (61%). A 10 year increase in age was associated with a significantly higher risk of mortality (hazard ratio [HR] 1.34, 95% confidence interval [CI] [1.15-1.57]), intracranial bleeding (HR 1.49, 95% CI [1.10-2.02]), and non-intracranial bleeding (HR 1.30, 95% CI [1.09-1.56]), which was confirmed by a higher mean haemocompatibility score (1.37 vs. 0.77, oldest vs. youngest groups, respectively, P = 0.033). Older patients suffered from less device-related infections requiring systemic antibiotics. No age-related differences were observed in HF-related hospitalizations, ventricular arrhythmias, pump thrombosis, non-fatal thromboembolic events, or RV failure.

conclusionsIn the PCHF-VAD registry, higher age was associated with increased risk of mortality, and especially with increased risk of major bleeding, which is particularly relevant for the DT population. The risks of HF hospitalizations, pump thrombosis, ventricular arrhythmia, or RV failure were comparable. Strikingly, older patients had less device-related infections.

Indexed as

Heart-Assist DevicesHeart FailureThrombosisAgedArrhythmias, CardiacHumansRegistriesTreatment OutcomeAdvanced heart failureAgeDestination therapyLeft ventricular assist devicesSurvival

Identifiers

PMID36460627
PMCPMC10053271
OpenAlexW4310640216

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.