Evidence map›Paper›PMID 36460524›Full record

ArticleFertility and sterility2023

Markers of ovarian reserve as predictors of future fertility.

Benjamin S Harris, Anne Marie Jukic, Tracy Truong, Caroline T Nagle, Alaattin Erkanli, Anne Z Steiner

Open access · bronzeAbstract read
In one paragraph

Article in Fertility and sterility, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 60 citations in OpenAlex.

  1. Molecular mechanisms of folliculogenesis and oogenesis.Systems biology in reproductive medicine · 2026
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  4. Anti-Müllerian hormone and somatic ovarian function: a new perspective.Journal of assisted reproduction and genetics · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Benjamin S HarrisDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Duke Fertility Center, Morrisville, North Carolina. Electronic address: bharris17@gmail.com.
Anne Marie JukicEpidemiology Branch, National Institute of Environmental Health Sciences, Durham, North Carolina.
Tracy TruongDepartment of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, North Carolina.
Caroline T NagleClinical Research Unit, Department of Obstetrics and Gynecology, Durham, North Carolina.
Alaattin ErkanliDepartment of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, North Carolina.
Anne Z SteinerDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Duke Fertility Center, Morrisville, North Carolina.
Duke University · USNational Institute of Environmental Health Sciences · USNorth Carolina Institute of Medicine · US

Funding

Support for QA/QC for Prior Approval ProcessUL1TR002553 · NCATS · DUKE UNIVERSITY · PI LI, JENNIFER S, MCNAMARA, JAMES O. · 2018 to 2023
$58.5M
Environmental influences on fertility and reproductive healthZIAES103333 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI JUKIC, ANNE MARIE · 2019 to 2025
$7.3M
Biomarkers of InfertilityR01HD067683 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI STEINER, ANNE ZWEIFEL · 2011 to 2015
$2.7M
Time to ConceiveR21HD060229 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI STEINER, ANNE ZWEIFEL · 2009 to 2010
$407k
NCATS NIH HHS UL1 TR002553NICHD NIH HHS R01 HD067683NICHD NIH HHS R21 HD060229
6 · The paper itself

Abstract

objectiveTo determine the association between ovarian reserve biomarkers and future fertility among late reproductive-age women.

designCohort study of participants enrolled in Time to Conceive (TTC), a time-to-pregnancy cohort study of the ovarian reserve biomarkers.

settingCommunity. PATIENT(S): Women aged 30-44 years without a history of infertility who provided a blood sample at enrollment in TTC and who agreed to future follow-up. INTERVENTION(S): Not applicable. MAIN OUTCOME MEASURE(S): The primary outcomes were probability of achieving a live birth >3 years after enrollment in TTC, diagnosis of infertility at any time, and time-to-pregnancy in future pregnancy attempts. RESULT(S): Women with diminished ovarian reserve, defined as those with an antimüllerian hormone (AMH) level <0.7 ng/mL or follicle-stimulating hormone (FSH) level ≥10 mIU/mL, did not have low risk of future live birth (relative risk [RR], 1.32; 95% confidence interval [CI], 0.95-1.83 and RR, 1.28; 95% CI, 0.97-1.70, respectively) compared with women with normal ovarian reserve after adjusting for age at blood draw, race, obesity, use of hormonal contraception, and year of enrollment in original study. Among women in the cohort that attempted to conceive, there was not a significant association between diminished ovarian reserve, as measured by AMH or FSH, and risk of future infertility (RR, 0.65; 95% CI, 0.21-2.07 and RR,1.69; 95% CI, 0.86-3.31, respectively). Similarly, there was no association between AMH and FSH levels and future fecundability (fecundability ratio, 0.97; 95% CI, 0.59, 1.60; and fecundability ration, 0.86; 95% CI, 0.55-1.36, respectively).

conclusionDiminished ovarian reserve is not associated with reduced future reproductive capacity. Given the lack of association, women should be cautioned regarding use biomarkers of ovarian reserve as predictors of their future reproductive capacity.

Indexed as

Infertility, FemaleOvarian DiseasesOvarian ReserveAnti-Mullerian HormoneBiomarkersCohort StudiesFemaleFertilityFollicle Stimulating HormoneHumansPregnancyTime-to-PregnancyAnti-Mullerian HormoneBiomarkersFollicle Stimulating Hormoneantimüllerian hormonebiomarkersfertility potentialOvarian reserve

Identifiers

PMID36460524
PMCPMC10074834
OpenAlexW4310191823

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.