Evidence map›Paper›PMID 36460464›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2023

2-AG-Mediated Control of GABAergic Signaling Is Impaired in a Model of Epilepsy.

Roberto Colangeli, Maria Morena, Allison Werner, Roger J Thompson, Mario van der Stelt, Quentin J Pittman, Matthew N Hill, G Campbell Teskey

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Carvone derived cannabidiol enantiomers as novel anticonvulsants.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  3. Article
  4. Review
  5. Phytocannabinoids restore seizure-induced alterations in emotional behaviour in male rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Roberto ColangeliDepartment of Cell Biology and Anatomy, Hotchkiss Brain Institute, University of Calgary, Calgary AB T2N4N1, Canada r.colangeli@univpm.it.
Maria MorenaDepartment of Cell Biology and Anatomy, Hotchkiss Brain Institute, University of Calgary, Calgary AB T2N4N1, Canada.ORCID 0000-0001-6590-8130
Allison WernerDepartment of Cell Biology and Anatomy, Hotchkiss Brain Institute, University of Calgary, Calgary AB T2N4N1, Canada.
Roger J ThompsonDepartment of Cell Biology and Anatomy, Hotchkiss Brain Institute, University of Calgary, Calgary AB T2N4N1, Canada.
Mario van der SteltDepartment of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, 2333 CC, Leiden, The Netherlands.
Quentin J PittmanDepartment of Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary, Calgary, AB T2N4N1, Canada.ORCID 0000-0003-0984-7665
Matthew N HillDepartment of Cell Biology and Anatomy, Hotchkiss Brain Institute, University of Calgary, Calgary AB T2N4N1, Canada.
G Campbell TeskeyDepartment of Cell Biology and Anatomy, Hotchkiss Brain Institute, University of Calgary, Calgary AB T2N4N1, Canada.ORCID 0000-0002-8462-355X

Funding

CIHR MOP-130495CIHR PJT-159454
6 · The paper itself

Abstract

Repeated seizures result in a persistent maladaptation of endocannabinoid (eCB) signaling, mediated part by anandamide signaling deficiency in the basolateral amygdala (BLA) that manifests as aberrant synaptic function and altered emotional behavior. Here, we determined the effect of repeated seizures (kindling) on 2-arachidonoylglycerol (2-AG) signaling on GABA transmission by directly measuring tonic and phasic eCB-mediated retrograde signaling in an

Indexed as

EndocannabinoidsEpilepsyAnimalsCannabinoid Receptor AgonistsDrug Inverse AgonismEnzyme Inhibitorsgamma-Aminobutyric AcidMaleRatsReceptor, Cannabinoid, CB1Receptors, CannabinoidSeizuresCannabinoid Receptor AgonistsEndocannabinoidsEnzyme Inhibitorsgamma-Aminobutyric AcidReceptor, Cannabinoid, CB1Receptors, CannabinoidelectrophysiologyendocannabinoidsepilepsyGABAkindlingsynaptic plasticity

Identifiers

PMID36460464
PMCPMC9888507

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.