ArticleNeuron2023
Hemispherically lateralized rhythmic oscillations in the cingulate-amygdala circuit drive affective empathy in mice.
Article in Neuron, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 43 citations in OpenAlex.
- GABA signaling in NG2 glia mediates empathy-like behavior under observational social defeat.Nature communications · 2026Article
- Divergent BLA engram circuits orchestrate social preference dynamics in bystander male mice with self-experienced stress.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Pupillometry and brain-wide c-Fos mapping uncover multimodal mirror emotional contagion related networks of mice.iScience · 2026Article
- Empathy and prosocial behavior powered by orexin-driven theta oscillations.Science (New York, N.Y.) · 2026Article
- Harnessing the Neurobiology of Empathy and Compassion to Alleviate Burnout in Neurology.Annals of neurology · 2026Review
- Heightened empathic responses led by imbalanced cortico-amygdala circuit inbioRxiv : the preprint server for biology · 2025Article
- The lateralized LC-NAergic system distinguishes vicarious versus direct fear in mice.Nature communications · 2025Article
- Roles of mediodorsal thalamus in observational fear-related neural activity in mouse anterior cingulate cortex.Molecular brain · 2025Article
- Cortical representations of affective pain shape empathic fear in male mice.Nature communications · 2025Article
- Reduced Modulation of Theta and Beta Oscillations Mediates Empathy Impairment in Parkinson's Disease.Brain and behavior · 2025Article
- Parietal-Frontal Pathway Controls Relapse of Fear Memory in a Novel Context.Biological psychiatry global open science · 2024Article
- An unbiased method to partition diverse neuronal responses into functional ensembles reveals interpretable population dynamics during innate social behavior.bioRxiv : the preprint server for biology · 2024Article
- Effect of Xiaoyaosan on brain volume and microstructure diffusion changes to exert antidepressant-like effects in mice with chronic social defeat stress.Frontiers in psychiatry · 2024Article
- Neuronal mechanism of innate rapid processing of threating animacy cue in primates: insights from the neuronal responses to snake images.Frontiers in psychology · 2024Review
- Understanding Others' Distress Through Past Experiences: The Role of Memory Engram Cells in Observational Fear.Advances in neurobiology · 2024Review
- Advances in neural circuits of innate fear defense behavior.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2023Review
- Social circuits and their dysfunction in autism spectrum disorder.Molecular psychiatry · 2023Review
- Threat gates visual aversion via theta activity in Tachykinergic neurons.Nature communications · 2023Article
- Systems consolidation induces multiple memory engrams for a flexible recall strategy in observational fear memory in male mice.Nature communications · 2023Article
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9 authors at 4 institutions in 3 countries.
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Abstract
Observational fear, a form of emotional contagion, is thought to be a basic form of affective empathy. However, the neural process engaged at the specific moment when socially acquired information provokes an emotional response remains elusive. Here, we show that reciprocal projections between the anterior cingulate cortex (ACC) and basolateral amygdala (BLA) in the right hemisphere are essential for observational fear, and 5-7 Hz neural oscillations were selectively increased in those areas at the onset of observational freezing. A closed-loop disruption demonstrated the causal relationship between 5-7 Hz oscillations in the cingulo-amygdala circuit and observational fear responses. The increase/decrease in theta power induced by optogenetic manipulation of the hippocampal theta rhythm bi-directionally modulated observational fear. Together, these results indicate that hippocampus-dependent 5-7 Hz oscillations in the cingulo-amygdala circuit in the right hemisphere are the essential component of the cognitive process that drives empathic fear, but not freezing, in general.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.