Evidence map›Paper›PMID 36460006›Full record

ReviewNeuron2023

Rethinking retrosplenial cortex: Perspectives and predictions.

Andrew S Alexander, Ryan Place, Michael J Starrett, Elizabeth R Chrastil, Douglas A Nitz

Abstract readReview
In one paragraph

Review in Neuron, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Spatial memory under emotion: Effects across encoding, maintenance and retrieval.British journal of psychology (London, England : 1953) · 2026
    Article
  4. Article
  5. Ecological Visual Processing in the Mouse.Annual review of neuroscience · 2026
    Review
  6. Review
  7. Causal and directional elements of global brain dynamics.bioRxiv : the preprint server for biology · 2026
    Article
  8. Article
  9. Reciprocal molecular and cellular cholinergic working memory impairments in Alzheimer's disease model mice.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Distinct Mechanisms for Panoramic and Landmark-Based View Integration in Human Place-Selective Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  17. Article
  18. Article
  19. Article
  20. Article

19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Andrew S AlexanderDepartment of Psychological and Brain Sciences, Boston University, Boston, MA 02215, USA.
Ryan PlaceDepartment of Cognitive Science, University of California, San Diego, La Jolla, CA 92093, USA.
Michael J StarrettDepartment of Neurobiology & Behavior, University of California, Irvine, Irvine, CA 92697, USA.
Elizabeth R ChrastilDepartment of Neurobiology & Behavior, University of California, Irvine, Irvine, CA 92697, USA; Department of Cognitive Sciences, University of California, Irvine, Irvine, CA 92697, USA. Electronic address: chrastil@uci.edu.
Douglas A NitzDepartment of Cognitive Science, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: dnitz@ucsd.edu.

Funding

Subiculm circuits for cortical feedback regulation of spatial mapping and learningR01NS104897 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI NITZ, DOUGLAS ARTHUR, XU, XIANGMIN · 2018 to 2022
$2.6M
Training in Translational ADRD Neuroscience (TITAN)T32AG073088 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Joshua Grill, Elizabeth Head · 2021 to 2026
$2.2M
Retrosplenial Cortex Circuit Interactions Supporting Spatial Cognition and MemoryK99NS119665 · NINDS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI ALEXANDER, ANDREW S. · 2021 to 2022
$241k
NIA NIH HHS T32 AG073088NINDS NIH HHS K99 NS119665NINDS NIH HHS R01 NS104897
6 · The paper itself

Abstract

The last decade has produced exciting new ideas about retrosplenial cortex (RSC) and its role in integrating diverse inputs. Here, we review the diversity in forms of spatial and directional tuning of RSC activity, temporal organization of RSC activity, and features of RSC interconnectivity with other brain structures. We find that RSC anatomy and dynamics are more consistent with roles in multiple sensorimotor and cognitive processes than with any isolated function. However, two more generalized categories of function may best characterize roles for RSC in complex cognitive processes: (1) shifting and relating perspectives for spatial cognition and (2) prediction and error correction for current sensory states with internal representations of the environment. Both functions likely take advantage of RSC's capacity to encode conjunctions among sensory, motor, and spatial mapping information streams. Together, these functions provide the scaffold for intelligent actions, such as navigation, perspective taking, interaction with others, and error detection.

Indexed as

Gyrus CinguliSpatial NavigationCerebral CortexCognitionallocentricegocentricepisodic memorynavigationnetwork oscillationsorientationperspective takingpredictive codingspatial transformationtemporal sequence

Identifiers

PMID36460006
PMCPMC11709228

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.