Evidence map›Paper›PMID 36459973›Full record

ArticleStructure (London, England : 1993)2022

Protein kinase inhibitor selectivity "hinges" on evolution.

Safal Shrestha, George Bendzunas, Natarajan Kannan

Abstract readComment
PubMed Publisher
In one paragraph

Article in Structure (London, England : 1993), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Slower CDK4 and faster CDK2 activation in the cell cycle.Structure (London, England : 1993) · 2024
    Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Safal ShresthaInstitute of Bioinformatics, University of Georgia, Athens, GA 30602, USA.
George BendzunasDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA.
Natarajan KannanInstitute of Bioinformatics, University of Georgia, Athens, GA 30602, USA; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA. Electronic address: nkannan@uga.edu.
University of Georgia · US

Funding

Unlocking sequence-structure-function-disease relationships in large protein super-familiesR35GM139656 · NIGMS · UNIVERSITY OF GEORGIA · PI KANNAN, NATARAJAN · 2021 to 2025
$2.2M
A data analytics framework for mining the dark kinomeU01CA239106 · NCI · UNIVERSITY OF GEORGIA · PI KANNAN, NATARAJAN, KOCHUT, KRZYSZTOF J · 2019 to 2021
$1.3M
NCI NIH HHS U01 CA239106NIGMS NIH HHS R35 GM139656
6 · The paper itself

Abstract

In this issue of Structure, Kelso et al. present the crystal structure of the understudied cancer-associated cyclin-dependent kinase 11 (CDK11) bound to the selective inhibitor OTS964, illuminating how evolutionary variations in the kinase domain can be exploited for inhibitor selectivity even among closely related kinases.

Indexed as

Antineoplastic AgentsProtein Kinase InhibitorsAntineoplastic AgentsProtein Kinase Inhibitors

Identifiers

PMID36459973
OpenAlexW4310775054

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.