Evidence map›Paper›PMID 36459648›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

DHX15 is involved in SUGP1-mediated RNA missplicing by mutant SF3B1 in cancer.

Jian Zhang, Ji Huang, Ke Xu, Peiqi Xing, Yue Huang, Zhaoqi Liu, Liang Tong, James L Manley

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
3.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 46 citations in OpenAlex.

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  16. Cancer-associated SF3B1 mutation K700E causes widespread changes in U2/branchpoint recognition without altering splicing.Proceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Jian ZhangDepartment of Biological Sciences, Columbia University, New York, NY 10027.ORCID 0000-0001-7565-1471
Ji HuangDepartment of Biological Sciences, Columbia University, New York, NY 10027.ORCID 0000-0001-6547-9727
Ke XuDepartment of Biological Sciences, Columbia University, New York, NY 10027.
Peiqi XingChinese Academy of Sciences Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China.ORCID 0000-0002-5675-1036
Yue HuangChinese Academy of Sciences Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China.
Zhaoqi LiuChinese Academy of Sciences Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China.ORCID 0000-0002-3798-9583
Liang TongDepartment of Biological Sciences, Columbia University, New York, NY 10027.ORCID 0000-0002-0563-6468
James L ManleyDepartment of Biological Sciences, Columbia University, New York, NY 10027.
Columbia University · USChinese Academy of Sciences · CN

Funding

User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI Nozomi Ando, J Christopher Fromme · 2018 to 2026
$34.2M
Regulation of RNA processing: Mechanisms and ConsequencesR35GM118136 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI James L. Manley · 2016 to 2026
$8.9M
Structural and functional studies of mRNA processing, stability and quality controlR35GM118093 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI LIANG TONG · 2016 to 2026
$8.5M
NIGMS NIH HHS P30 GM124165NIGMS NIH HHS R35 GM118093NIGMS NIH HHS R35 GM118136
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

NeoplasmsRNA HelicasesRNA SplicingRNA Splicing FactorsDNA HelicasesGenes, RegulatorHumansPhosphoproteinsSpliceosomesDHX15 protein, humanDNA HelicasesPhosphoproteinsRNA HelicasesRNA Splicing FactorsSF3B1 protein, humanSUGP1 protein, humanG-patchhelicaseleukemiamyelodysplastic syndromesspliceosome

Identifiers

PMID36459648
PMCPMC9894173
OpenAlexW4311183751

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.