ArticleProceedings of the National Academy of Sciences of the United States of America2022
Trabecular bone ontogeny tracks neural development and life history among humans and non-human primates.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Growing together: Developmental integration and modularity in the human talus-calcaneus complex.Journal of anatomy · 2026Article
- Too Many Bones to Pick - from Overproduction to Refinement: Evidence for Trabecular Pruning in Early Postnatal Development as a Distinct Phase of Skeletal Functional Adaptation.Annals of biomedical engineering · 2026Review
- Trabecular Architecture of the Proximal Tibia in Extant Hominids.American journal of biological anthropology · 2025Article
- Investigating Development in Human Evolution: Specificities, Challenges, and Opportunities.Evolutionary anthropology · 2025Review
- The Ontogeny of the Human Calcaneus: Insights From Morphological and Trabecular Changes During Postnatal Growth.American journal of biological anthropology · 2025Article
- Trabecular Bone Ontogeny of the Human Distal Tibia.American journal of biological anthropology · 2025Article
- A new biomechanical model of the mammal jaw based on load path analysis.The Journal of experimental biology · 2024Article
- The ontogeny of human fetal trabecular bone architecture occurs in a limb-specific manner.Scientific reports · 2024Article
- Trabecular architecture of the distal femur in extant hominids.Journal of anatomy · 2024Article
- Raccoons Reveal Hidden Diversity in Trabecular Bone Development.Integrative organismal biology (Oxford, England) · 2024Article
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Authors and funding
4 authors at 4 institutions in 3 countries.
Funding
Abstract
Trabecular bone-the spongy bone inside marrow cavities-adapts to its mechanical environment during growth and development. Trabecular structure can therefore be interpreted as a functional record of locomotor behavior in extinct vertebrates. In this paper, we expand upon traditional links between form and function by situating ontogenetic trajectories of trabecular bone in four primate species into the broader developmental context of neural development, locomotor control, and ultimately life history. Our aim is to show that trabecular bone structure provides insights into ontogenetic variation in locomotor loading conditions as the product of interactions between increases in body mass and neuromuscular maturation. Our results demonstrate that age-related changes in trabecular bone volume fraction (BV/TV) are strongly and linearly associated with ontogenetic changes in locomotor kinetics. Age-related variation in locomotor kinetics and BV/TV is in turn strongly associated with brain and body size growth in all species. These results imply that age-related variation in BV/TV is a strong proxy for both locomotor kinetics and neuromuscular maturation. Finally, we show that distinct changes in the slope of age-related variation in bone volume fraction correspond to the age of the onset of locomotion and the age of locomotor maturity. Our findings compliment previous studies linking bone development to locomotor mechanics by providing a fundamental link to brain development and life history. This implies that trabecular structure of fossil subadults can be a proxy for the rate of neuromuscular maturation and major life history events like locomotor onset and the achievement of adult-like locomotor repertoires.
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