ArticleScience advances2022
Widespread formation of toxic nitrated bisphenols indoors by heterogeneous reactions with HONO.
Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 40 citations in OpenAlex.
- Enantioselective protein affinity selection mass spectrometry (E-ASMS).Nature communications · 2025Article
- Liquid crystal monomers induce placental development and progesterone release dysregulation through transplacental transportation.Nature communications · 2025Article
- Insights into the Chemical Exposome during Pregnancy: A Non-Targeted Analysis of Preterm and Term Births.Environmental science & technology · 2024Article
- Hydroxyl radical oxidation of chemical contaminants on indoor surfaces and dust.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Unveiling the underestimated direct emissions of nitrous acid (HONO).Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Toxicological Effects of Secondary Air Pollutants.Chemical research in Chinese universities · 2023Review
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With numerous structurally diverse indoor contaminants, indoor transformation chemistry has been largely unexplored. Here, by integrating protein affinity purification and nontargeted mass spectrometry analysis (PUCA), we identified a substantial class of previously unrecognized indoor transformation products formed through gas-surface reactions with nitrous acid (HONO). Through the PUCA, we identified a noncommercial compound, nitrated bisphenol A (BPA), from house dust extracts strongly binding to estrogen-related receptor γ. The compound was detected in 28 of 31 house dust samples with comparable concentrations (ND to 0.30 μg/g) to BPA. Via exposing gaseous HONO to surface-bound BPA, we demonstrated it likely forms via a heterogeneous indoor chemical transformation that is highly selective toward bisphenols with electron-rich aromatic rings. We used
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.