ArticleScience advances2022
Discovery of BODIPY J-aggregates with absorption maxima beyond 1200 nm for biophotonics.
Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Fluorescent J‑Aggregates in the NIR-II Window: Unlocking Frontiers in Biomedical Imaging.Chemical & biomedical imaging · 2026Review
- Recent advances in photodynamic therapy systems based on pillar[n]arene host-guest chemistry.Frontiers in chemistry · 2026Review
- S···O Conformation Locks Synergistic Alkoxy Chain Engineering of NIR-II Phototheranostic Molecules for Precision Hepatocellular Carcinoma Theranostics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Streamlined construction of boron-stereogenic BODIPY library for near-infrared bioimaging.Nature communications · 2025Article
- Stable Ultrabroad-Absorbing Radical Achieves Efficient NIR-II Photothermal Conversion via Facile Synthesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Aggregation Behavior of CHR-bis(BODIPY) Bichromophores in THF-water Mixtures: Effect of Linking Positions and Aryl-spacer Substituents.Journal of fluorescence · 2025Article
- Constructing J-aggregates of cyanine dye for NIR-II in vivo dynamic vascular imaging and long-term targeting of tumors.Materials today. Bio · 2025Article
- Electrostatic Co-Assembly of Cyanine Pair for Augmented Photoacoustic Imaging and Photothermal Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- NIR-II-activated whole-cell vaccine with ultra-efficient semiconducting diradical oligomers for breast carcinoma growth and metastasis inhibition.Acta pharmaceutica Sinica. B · 2025Article
- Recent Advances in Strategies to Enhance Photodynamic and Photothermal Therapy Performance of Single-Component Organic Phototherapeutic Agents.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Supramolecular engineering cascade regulates NIR-II J-aggregates to improve photodynamic therapy.Chemical science · 2024Article
- Supramolecular dye nanoassemblies for advanced diagnostics and therapies.Bioengineering & translational medicine · 2024Review
- Rational design of CT-coupled J-aggregation platform based on Aza-BODIPY for highly efficient phototherapy.Chemical science · 2024Article
- A thermoresponsive nanocomposite integrates NIR-II-absorbing small molecule with lonidamine for pyroptosis-promoted synergistic immunotherapy.Journal of nanobiotechnology · 2024Article
- Bright, photostable and long-circulating NIR-II nanoparticles for whole-process monitoring and evaluation of renal transplantation.National science review · 2024Article
- High-Performance Hybrid Phototheranostics for NIR-IIb Fluorescence Imaging and NIR-II-Excitable Photothermal Therapy.Pharmaceutics · 2023Article
- Molecular Design of NIR-II Polymethine Fluorophores for Bioimaging and Biosensing.Chemical & biomedical imaging · 2023Review
- THQ-Xanthene: An Emerging Strategy to Create Next-Generation NIR-I/II Fluorophores.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Organic dyes with absorption maxima in the second near-infrared window (NIR-II; 1000 to 1700 nm) are of great interest in biophotonics. However, because of the lack of appropriate molecular scaffolds, current research in this field is limited to cyanine dyes, and developing NIR-II-absorbing organic dyes for biophotonics remains an immense challenge. Here, we rationally designed an ethenylene-bridged BODIPY scaffold featuring excellent J-aggregation capabilities and revealed that the bridging ethylene unit is crucial for intermolecular J-coupling regulation. By integrating the electron-donating groups into the scaffold, we obtained a BODIPY dye, BisBDP2, with a J-aggregate absorption maximum of around 1300 nm. BisBDP2 J-aggregates show excellent photothermal performance, including intense photoacoustic response, and a high photothermal conversion efficiency value of 63%. In vivo results demonstrate the potential of J-aggregates for photoacoustic imaging and photothermal ablation of deep-seated tumors. This study will speed up the exploration of NIR-II-absorbing J-aggregates for future biophotonic applications.
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Registered trials
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