ArticleScience advances2022
Deep brain stimulation of the subgenual cingulum and uncinate fasciculus for the treatment of posttraumatic stress disorder.
Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Next-Generation Neuromodulation for Anxiety: Circuit-Based and Personalized Approaches.Current psychiatry reports · 2026Review
- Good vibrations: Sternal vibration enhances white matter density and interoceptive awareness.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- From lobotomy to connectomics: a critical review of contemporary psychosurgery.Frontiers in psychiatry · 2026Review
- Good vibrations: Sternal vibration enhances white matter density and interoceptive awareness.Research square · 2025Article
- Interventional Psychiatry and Emerging Treatments for Posttraumatic Stress Disorder (PTSD): A Systematic Review.Psychiatry and clinical psychopharmacology · 2025Article
- White matter correlates of dissociation in a diverse sample of trauma-exposed women.Psychiatry research · 2024Article
- A potential target for noninvasive neuromodulation of PTSD symptoms derived from focal brain lesions in veterans.Nature neuroscience · 2024Article
- Deep brain stimulation of the amygdala for treatment-resistant combat post-traumatic stress disorder: Long-term results.Journal of psychiatric research · 2024Article
- A potential neuromodulation target for PTSD in Veterans derived from focal brain lesions.Research square · 2024Article
- Insertional effect following electrode implantation: an underreported but important phenomenon.Brain communications · 2024Review
- A pilot study of closed-loop neuromodulation for treatment-resistant post-traumatic stress disorder.Nature communications · 2023Article
- Article
- Analysis of the influences of social isolation on cognition and the therapeutic potential of deep brain stimulation in a mouse model.Frontiers in psychiatry · 2023Article
- Regional associations of white matter integrity and neurological, post-traumatic stress disorder and autonomic symptoms in Veterans with and without history of loss of consciousness in mild TBI.Frontiers in neuroimaging · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
13 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Deep brain stimulation (DBS) has been investigated for neuropsychiatric disorders. In this phase 1 trial, we treated four posttraumatic stress disorder (PTSD) patients with DBS delivered to the subgenual cingulum and the uncinate fasciculus. In addition to validated clinical scales, patients underwent neuroimaging studies and psychophysiological assessments of fear conditioning, extinction, and recall. We show that the procedure is safe and potentially effective (55% reduction in Clinical Administered PTSD Scale scores). Posttreatment imaging data revealed metabolic activity changes in PTSD neurocircuits. During psychophysiological assessments, patients with PTSD had higher skin conductance responses when tested for recall compared to healthy controls. After DBS, this objectively measured variable was significantly reduced. Last, we found that a ratio between recall of extinguished and nonextinguished conditioned responses had a strong correlation with clinical outcome. As this variable was recorded at baseline, it may comprise a potential biomarker of treatment response.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.