Evidence map›Paper›PMID 36459450›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2023

Tissue inhibitor of metalloproteinase-4 deletion in mice impacts maternal cardiac function during pregnancy and postpartum.

Ashley A Thurstin, Allison N Egeli, Edie C Goldsmith, Francis G Spinale, Holly A LaVoie

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. From bump to pump: extracellular matrix remodeling, dynamics, and biomechanics in the maternal heart.American journal of physiology. Heart and circulatory physiology · 2026
    Review
  2. Review
  3. Hyaluronan in cardiac disease: implications for the extracellular matrix beyond collagen.American journal of physiology. Heart and circulatory physiology · 2026
    Review
  4. Article
  5. Sex as a biological variable for cardiovascular physiology.American journal of physiology. Heart and circulatory physiology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ashley A ThurstinDepartment of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina.
Allison N EgeliDepartment of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina.
Edie C GoldsmithDepartment of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina.
Francis G SpinaleDepartment of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina.ORCID 0000-0003-0529-5605
Holly A LaVoieDepartment of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina.ORCID 0000-0002-6658-549X
University of South Carolina · US

Funding

South Carolina IDeA Networks of Biomedical Research (SC INBRE V)P20GM103499 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI EDIE C GOLDSMITH · 2012 to 2026
$61.0M
NIGMS NIH HHS P20 GM103499
6 · The paper itself

Abstract

Reversible physiological cardiac hypertrophy of the maternal heart occurs during pregnancy and involves extracellular matrix (ECM) remodeling. Previous mouse studies revealed that changes in ECM molecules accompany functional changes in the left ventricle (LV) during late pregnancy and postpartum. We evaluated the effect of global

Indexed as

HeartTissue Inhibitor of MetalloproteinasesVentricular RemodelingAnimalsFemaleMiceMice, KnockoutPostpartum PeriodPregnancyStroke VolumeTissue Inhibitor of Metalloproteinase-4Tissue Inhibitor of Metalloproteinase-4Tissue Inhibitor of Metalloproteinasesechocardiographyextracellular matrixheart functionlactationpregnancy

Identifiers

PMID36459450
PMCPMC9799138
OpenAlexW4310597859

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.