ReviewPulmonary therapy2023
Tests and Indices Predicting Extubation Failure in Children: A Systematic Review and Meta-analysis.
Review in Pulmonary therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Diaphragmatic Ultrasonography as a Predictor of Extubation Success in Children: Systematic Review and Meta-Analysis.Pediatric pulmonology · 2026Pooled it
- The Practice of Extubation Readiness Testing in Pediatric Cardiac Intensive Care Units: A Cross-sectional Study Based on an Electronic Survey.CJC pediatric and congenital heart disease · 2026Article
- Weight-adjusted rapid shallow breathing index during spontaneous breathing trial in mechanically ventilated preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Risk Factors and Clinical Outcomes of Post-Extubation Stridor in Pediatric Intensive Care.Children (Basel, Switzerland) · 2025Article
- [ Extubation failure predictors in the release process of invasive mechanical ventilatory support in pediatrics]Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina) · 2025Article
- Expert-augmented machine learning for predicting extubation readiness in the pediatric intensive care unit.BMC medical informatics and decision making · 2025Article
- Personalizing ICU liberation for critically Ill children: shaping the future of the ABCDEF bundle.Current opinion in pediatrics · 2025Review
- Transcutaneous Carbon Dioxide Monitoring During Weaning From Mechanical Ventilation in Children: The WeanCOPediatric pulmonology · 2025Article
- Risk factors analysis and research on the construction of early prediction model of difficult weaning in children with mechanical ventilation.Frontiers in pediatrics · 2025Article
- Overnight extubation and risk of extubation failure in patients in the pediatric intensive care unit: an exploratory review.Frontiers in pediatrics · 2025Review
- Prognostic factors for successful extubation in newborns with congenital diaphragmatic hernia.Frontiers in pediatrics · 2025Article
- Article
- Implementing the Pediatric Ventilator Liberation Guidelines Using the Most Current Evidence.Respiratory care · 2024Review
- Predictors and outcomes of extubation failures in a pediatric intensive care unit: A retrospective study.Journal of Taibah University Medical Sciences · 2024Article
- Predictive parameters and model for extubation outcome in pediatric patients.Frontiers in pediatrics · 2023Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
introductionThere is lack of consensus on what constitutes best practice when assessing extubation readiness in children. This systematic review aims to synthesize data from existing literature on pre-extubation assessments and evaluate their diagnostic accuracies in predicting extubation failure (EF) in children.
methodsA systematic search in PubMed, EMBASE, Web of Science, CINAHL, and Cochrane was performed from inception of each database to 15 July 2021. Randomized controlled trials or observational studies that studied the association between pre-extubation assessments and extubation outcome in the pediatric intensive care unit population were included. Meta-analysis was performed for studies that report diagnostic tests results of a combination of parameters.
resultsIn total, 41 of 11,663 publications screened were included (total patients, n = 8111). Definition of EF across studies was heterogeneous. Fifty-five unique pre-extubation assessments were identified. Parameters most studied were: respiratory rate (RR) (13/41, n = 1945), partial pressure of arterial carbon dioxide (10/41, n = 1379), tidal volume (13/41, n = 1945), rapid shallow breathing index (RBSI) (9/41, n = 1400), and spontaneous breathing trials (SBT) (13/41, n = 5652). Meta-analysis shows that RSBI, compliance rate oxygenation pressure (CROP) index, and SBT had sensitivities ranging from 0.14 to 0.57. CROP index had the highest sensitivity [0.57, 95% confidence interval (CI) 0.4-0.73] and area under curve (AUC, 0.98). SBT had the highest specificity (0.93, 95% CI 0.92-0.94).
conclusionsPre-extubation assessments studied thus far remain poor predictors of EF. CROP index, having the highest AUC, should be further explored as a predictor of EF. Standardizing the EF definition will allow better comparison of pre-extubation assessments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.