ArticleThe Journal of clinical endocrinology and metabolism2023
Association of Longitudinal Activity Measures and Diabetes Risk: An Analysis From the National Institutes of Health All of Us Research Program.
Article in The Journal of clinical endocrinology and metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 22 citations in OpenAlex.
- Reminder Strategies to Improve Meal-Logging Adherence: Protocol for a Microrandomized Trial.JMIR research protocols · 2026Article
- Social Determinants of Daily Step Count in Young Adults With and Without Prediabetes and Type 2 Diabetes.Journal of physical activity & health · 2026Article
- Digital Phenotyping in Health Research: Scoping Review of Methods, Gaps, and Opportunities.Journal of medical Internet research · 2026Article
- Accelerometer-derived physical activity, sarcopenia, and grip strength as modifiers of type 2 diabetes risk.Scientific reports · 2026Article
- Predicting incident type 2 diabetes using wearable activity and polygenic risk: A survival-modeling study in All of Us.The Journal of clinical endocrinology and metabolism · 2026Article
- Wearable devices and cardiovascular health: revolutionizing remote monitoring and disease prevention.European heart journal · 2026Review
- Daily steps offset risks of sedentary behavior in the All of Us research program.Nature communications · 2026Article
- Association of chronic disease risk and physical activity measured by wearable devices in the All of Us program.Communications medicine · 2026Article
- Bibliometric Analysis of Emerging Trends and Hotspots in the Links between Nonalcoholic Steatohepatitis and Diabetes Mellitus from 2004 to 2023.Endocrine, metabolic & immune disorders drug targets · 2026Review
- Not all steps are equal: independent prospective associations of stepping volume and patterns with incident type 2 diabetes mellitus in the Maastricht study.The international journal of behavioral nutrition and physical activity · 2025Article
- The distinct landscape of tumor immune microenvironment in homologous recombination deficient cancers.Biomarker research · 2025Review
- Trajectories of mHealth-Tracked Mental Health and Their Predictors in Female Chronic Pelvic Pain Disorders.Journal of pain research · 2025Article
- Sleep patterns and risk of chronic disease as measured by long-term monitoring with commercial wearable devices in the All of Us Research Program.Nature medicine · 2024Article
- Biometrics of complete human pregnancy recorded by wearable devices.NPJ digital medicine · 2024Article
- The Bitemporal Lens Model-toward a holistic approach to chronic disease prevention with digital biomarkers.JAMIA open · 2024Review
- Physical activity decreases in patients on the liver transplant waiting list and influences postoperative outcome-a prospective cohort study.Hepatobiliary surgery and nutrition · 2024Article
- Physical Activity Over the Lifecourse and Cardiovascular Disease.Circulation research · 2023Review
- Obesity, diabetes mellitus, and cardiometabolic risk: An Obesity Medicine Association (OMA) Clinical Practice Statement (CPS) 2023.Obesity pillars · 2023Article
- Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 1 country.
Funding
Abstract
contextPrior studies of the relationship between physical activity and incident type 2 diabetes mellitus (T2DM) relied primarily on questionnaires at a single time point.
objectiveWe sought to investigate the relationship between physical activity and incident T2DM with an innovative approach using data from commercial wearable devices linked to electronic health records in a real-world population.
methodsUsing All of Us participants' accelerometer data from their personal Fitbit devices, we used a time-varying Cox proportional hazards models with repeated measures of physical activity for the outcome of incident T2DM. We evaluated for effect modification with age, sex, body mass index (BMI), and sedentary time using multiplicative interaction terms.
resultsFrom 5677 participants in the All of Us Research Program (median age 51 years; 74% female; 89% White), there were 97 (2%) cases of incident T2DM over a median follow-up period of 3.8 years between 2010 to 2021. In models adjusted for age, sex, and race, the hazard of incident diabetes was reduced by 44% (95% CI, 15%-63%; P = 0.01) when comparing those with an average daily step count of 10 700 to those with 6000. Similar benefits were seen comparing groups based on average duration of various intensities of activity (eg, lightly active, fairly active, very active). There was no evidence for effect modification by age, sex, BMI, or sedentary time.
conclusionGreater time in any type of physical activity intensity was associated with lower risk of T2DM irrespective of age, sex, BMI, or sedentary time.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.