Evidence map›Paper›PMID 36458537›Full record

ArticleJournal of cellular and molecular medicine2022

Bacteroides plebeius improves muscle wasting in chronic kidney disease by modulating the gut-renal muscle axis.

Tingting Pei, Daoqi Zhu, Sixia Yang, Rong Hu, Fujing Wang, Jiaxing Zhang, Shihua Yan, Liliang Ju, Zhuoen He, Zhongxiao Han and 5 more

Open access · goldAbstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Tingting PeiDepartment of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Daoqi ZhuDepartment of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Sixia YangDepartment of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Rong HuDepartment of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Fujing WangDepartment of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Jiaxing ZhangDepartment of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Shihua YanDepartment of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Liliang JuDepartment of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Zhuoen HeDepartment of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Zhongxiao HanDepartment of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Jinyue HeDepartment of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Yangtian YanDepartment of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Mingqing WangDepartment of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Wei XiaoDepartment of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Yun MaDepartment of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.ORCID 0000-0003-2370-0491
TCM-Intigrated Cancer Center of Southern Medical University · CNGuangdong Pharmaceutical University · CNNanfang Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic kidney disease (CKD) affects approximately 10% of the global population. Muscle atrophy occurs in patients with almost all types of CKD, and the gut microbiome is closely related to protein consumption during chronic renal failure (CRF). This study investigated the effects of Bacteroides plebeius on protein energy consumption in rats with CKD, and our results suggest that Bacteroides plebeius may combat muscle atrophy through the Mystn/ActRIIB/SMAD2 pathway. A total of 5/6 Nx rats were used as a model of muscle wasting in CKD. The rats with muscle wasting were administered Bacteroides plebeius (2 × 10

Indexed as

Renal Insufficiency, ChronicAnimalsBacteroidesDietary ProteinsMusclesMuscular AtrophyRatsDietary ProteinsBacteroides plebeiuschronic kidney diseaseintestinal microecologymuscle wasting

Identifiers

PMID36458537
PMCPMC9753468
OpenAlexW4310546190

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.